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tag techniques neuroscience dna methylation mutations disease medicine

First, Do No Harmā€¦
Jim Woodgett | Jun 9, 2011 | 5 min read
Is DNA damage an inevitable consequence of epigenetic reprogramming?
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Advances in Genome Editing
Catherine Offord | Apr 20, 2016 | 4 min read
Researchers develop a CRISPR-based technique that efficiently corrects point mutations without cleaving DNA.
Researchers Engineer Epigenome Editors to Study How Gene Expression Affects Disease
Ashley Yeager | Jan 1, 2019 | 7 min read
Using CRISPR and other tools, scientists are modifying DNA methylation, histone marks, and other modifiers of gene expression to understand how they affect health and disease.
Rare Disease Geneticist: A Profile of Uta Francke
Anna Azvolinsky | May 1, 2018 | 9 min read
The Stanford University human geneticist identified the genes and genomic abnormalities underlying numerous rare diseases, including Rett  syndrome, and advanced the field of molecular diagnostics. 
Exome Sequencing Helps Crack Rare Disease Diagnosis
Amanda B. Keener | May 1, 2018 | 10+ min read
Clinical analyses of patients’ gene sequences are helping to provide answers where none were available before.
Methylation: Gene Expression at the Right Place and Right Time
Nadia Halim | Dec 5, 1999 | 7 min read
Courtesy of Richard Roberts, New England BiolabsModel methylation reaction: Cytosine nucleotide (red) is flipped out of the DNA double helix by a methyltransferase (white), so it can be methylated. The end product after the methyl group has been transferred to the DNA is pictured in green. A tenuous link between DNA methylation and development has existed for several years. Now findings substantiate the connection. Researchers have found the first human diseases caused by defects in the DNA meth
Scanning electron micrograph (SEM) of the unicellular yeast Saccharomyces cerevisiae, known as Baker's or Brewer's yeast.
Yeast Models Provide New Insights into Neurodegenerative Diseases
Mahlon Collins | Oct 1, 2021 | 10+ min read
The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.
episignature epigenetics rare disease
Researchers Analyze Epigenetic Signatures to Diagnose Rare Diseases
Katarina Zimmer | Mar 28, 2019 | 5 min read
A number of rare diseases show unique epigenetic patterns across the genome, a feature researchers have now exploited to build a diagnostic tool.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.

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