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tag limb development stem cells bone growth developmental biology

3D rendered single cell next to a cluster of cells, illustrating the concept of stem cell differentiation and proliferation.
Selecting Cytokines for Organoid Cultures
The Scientist Staff | Mar 1, 2024 | 2 min read
Scientists optimize organoid culture growth and consistency with validated growth factor panels.
The Best of Experimental Biology
Edyta Zielinska | Apr 25, 2012 | 3 min read
From breast milk stem cells to bone repair, this year’s EB conference held a number of exciting advances that could one day be translated into therapies.
Woman smiling at the camera working out on a blue yoga mat.
Keeping Older Muscles Strong
Hannah Thomasy, PhD, Drug Discovery News | Sep 5, 2023 | 5 min read
From stem cell-recruiting gels to hormone cycle restoration, Tracy Criswell has big ideas about how to combat age-related decline in muscle regeneration.
Skeleton Keys
Lewis Wolpert | May 1, 2011 | 3 min read
There are a surprising number of unknowns about how our limbs come to be symmetrical.
Stem Cell Sculpting
Jack Lucentini | Aug 29, 2004 | 3 min read
SHAPING A COMMITMENT:© 2004 Cell PressBrightfield images of hMSCs plated onto small 1,024 μm2 or large 10,000 μm2 fibronectin islands after 1 week in growth or mixed media. Lipids stain red, alkaline phosphatase stains blue. Scale bar = 50 μm. (From R. McBeath et al., Dev Cell, 6:483–95, 2004)Researchers have tried for years to make stem cells differentiate into specific cell types. This work usually involves bathing the cells in molecular signals that affect their fate
Animals’ Embryonic Organizer Now Discovered in Human Cells
Jim Daley | May 23, 2018 | 4 min read
The finding confirms that a cluster of cells that directs the fate of other cells in the developing embryo is evolutionarily conserved across the animal kingdom.
Guts and Glory
Anna Azvolinsky | Apr 1, 2016 | 9 min read
An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.
New Workhorses of Stem Cell Technology
Ricki Lewis | Jan 21, 2001 | 5 min read
Most media reports on stem cell biology trace the field's origin to two key papers published in 1981.1,2 But Leroy Stevens at the Jackson Laboratory in Bar Harbor, Maine, laid the groundwork in mice from the 1950s through the 1970s, manipulating bizarre growths called embryoid bodies,3 to see what these cells would become. Embryoid bodies formed when cancer cells were transplanted into mouse abdomens. At first they appeared to be a ring of cells enclosing blood, debris, and a few unspecialized c
Human Mesenchymal Stem Cells Differentiate in the Lab
Ricki Lewis | Apr 11, 1999 | 5 min read
While prominent scientists plead with legislators to reconsider their conservative stance on funding human embryonic stem (ES) cell research, a six-year-old company in Baltimore is quietly making the matter moot. In a just-released tour-de-force research report, it is no longer quite so quiet.1 Researchers at Osiris Therapeutics and the Johns Hopkins University School of Medicine coaxed human mesenchymal stem cells (hMSCs) from adults' bone marrow to develop into cartilage, fat, and bone cells
Immune Cell–Stem Cell Cooperation
Sarthak Sinha, Jeff Biernaskie, and Waleed Rahmani | Jul 1, 2016 | 10+ min read
Understanding interactions between the immune system and stem cells could pave the way for successful stem cell–based regenerative therapies.

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