neuroscience, genetics

Using CRISPR to swap an archaic variant of the NOVA1 gene into human stem cells, researchers create organoids with neurodevelopmental differences from those carrying modern DNA.

An analysis of the contours of more than 600 kids’ brains points to links between cerebral surface area and heritability in regions of the brain important in cognition.  

Changes in gene expression also hint at how the brains of people with ASD develop differently from those of other people.

Geneticist and profilee Hoda Zoghbi describes her work on rare diseases.

One variant limited the brain’s ability to use glucose.

Upping a gene’s expression in rat brains made them better learners and normalized the activity of hundreds of other genes to resemble the brains of younger animals.

Researchers uncover the central role of a protein linked to Fragile X Syndrome in mice, one of the leading causes of autism and intellectual disability.

Researchers develop a new method to highlight specific cells that reside in the lens of a zebrafish.

Loss of the CLOCK protein, which researchers find is decreased in pediatric epilepsy patients, makes mice more prone to seizures during sleep.

Women with a notorious variant of a gene involved in Alzheimer’s, APOE4, are much more likely than men with the variant to develop the neurodegenerative disease.

Researchers are piecing together the devilishly complex sets of genetic alterations underlying schizophrenia and bipolar disorder.

Researchers have generated an image of thoughts flitting through the brains of zebrafish.

Recent results are as puzzling as they are beguiling, dredging up debates about the nature of language and the ability of a single gene to affect it so greatly.