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Can Destroying Senescent Cells Treat Age-Related Disease?
Can Destroying Senescent Cells Treat Age-Related Disease?
A handful of clinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age.
Can Destroying Senescent Cells Treat Age-Related Disease?
Can Destroying Senescent Cells Treat Age-Related Disease?

A handful of clinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age.

A handful of clinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age.

cell & molecular biology, disease & medicine

Genes that Escape Silencing on the Second X Chromosome May Drive Disease
Amber Dance | Mar 1, 2020 | 10+ min read
When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.
Infographic: How Does Cell Senescence Drive Aging and Disease?
Katarina Zimmer | Mar 1, 2020 | 4 min read
The accumulation of zombie-like cells seems to accelerate aging and promote aging-related disease. Researchers are trying to figure out how.
Inadequate Myelination of Neurons Tied to Autism: Study
Lisa Winter | Feb 4, 2020 | 2 min read
A mouse model of autism and postmortem brains of autistic individuals showed a lack of mature oligodendrocytes and less myelination than controls.
Novel DNA-Sensing Pathway Found in Human Cells, Absent in Mice
Catherine Offord | Jan 24, 2020 | 4 min read
This previously unknown mechanism for spotting foreign genetic material in the cytoplasm launches antiviral defenses even when the well-known immune mediator STING is absent.
a pair of scissors cuts a film strip that's curled into a helix
Alternative Splicing Provides a Broad Menu of Proteins for Cells
Gabrielle M. Gentile, Hannah J. Wiedner, Emma R. Hinkle, and Jimena Giudice | Jan 13, 2020 | 10+ min read
It’s now clear that gene transcripts can be constructed in various ways, yet many questions remain about the process.
Image of the Day: Repairing Hearts
Emily Makowski | Jan 7, 2020 | 2 min read
A growth factor treatment helps improve cardiac functioning after heart attack in pigs.
The Scientist Infographics: Editor’s Picks of 2019
Jef Akst | Dec 18, 2019 | 3 min read
This year’s most beautiful illustrations covered topics including the molecular underpinnings of Parkinson’s disease and strategies for tracking marine organisms around the world’s oceans.
Image of the Day: Inflamed Mouse Follicles
Emily Makowski | Dec 16, 2019 | 2 min read
Normal hair growth can lead to infection during cancer treatment.
Circulating Fetal Cells Sequenced for Prenatal Testing Study
Emily Makowski | Dec 10, 2019 | 3 min read
Trophoblasts, collected from the mother during a blood draw, can determine fetal genetic abnormalities currently diagnosed through amniocentesis or chorionic villi sampling.
Image of the Day: HIV Shuttles
Emily Makowski | Dec 5, 2019 | 1 min read
Macrophages transport HIV-like particles into lymph nodes during infection.
Sergiu Pasca Builds Brains to Study Developmental Disease
Emily Makowski | Dec 1, 2019 | 3 min read
The Stanford University professor helped develop a technique to grow brain organoids from induced pluripotent stem cells.
Exploring the Matrix: A Profile of Zena Werb
Diana Kwon | Dec 1, 2019 | 7 min read
The cell and molecular biologist unveiled a role for the breakdown of proteins in the extracellular matrix in both healthy and pathogenic cells.
Image of the Day: Cryptosporidiosis Treatment
Emily Makowski | Nov 8, 2019 | 1 min read
An enzyme blocker is highly effective at treating intestinal parasitic infection in mice.
Experimental TB Vaccine Partially Effective: Study
Ashley Yeager | Oct 30, 2019 | 2 min read
Tested in patients with the latent form of tuberculosis, the vaccine prevented the development of the active form of infection in 50 percent more individuals compared with unvaccinated patients.
Study Topic Influences Funding Disparity for Black Scientists
Ashley Yeager | Oct 10, 2019 | 2 min read
A new analysis finds that black scientists tend to propose projects that have lower rates of funding from the National Institutes of Health than other fields.
Is It Time to Rethink Parkinson’s Pathology?
Ashley Yeager | Oct 1, 2019 | 10+ min read
New evidence points to a waste-clearing problem in patients’ cells, rather than the accumulation of protein tangles, as the root cause of the neurodegenerative disease.
Air Pollution May Damage People’s Brains
Catherine Offord | Oct 1, 2019 | 10+ min read
Contaminants in the atmosphere appear to have harmful effects on neurodevelopment and cognitive function.
Why Immune Cells Extrude Webs of DNA and Protein
Borko Amulic and Gabriel Sollberger | Oct 1, 2019 | 10 min read
Extracellular webs expelled by neutrophils trap invading pathogens, but these newly discovered structures also have ties to autoimmunity and cancer.
Infographic: Is Cellular Waste at the Root of Parkinson’s Disease?
Ashley Yeager | Oct 1, 2019 | 1 min read
Damage to the lysosome, the organelle that removes excess proteins, lipids, and other materials, might be at the root of the disease.
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