disease & medicine, genetics & genomics

Two copies of the APOE4 variant, which confers a higher risk of dementia, doubles the risk of severe symptoms as a result of infection with SARS-CoV-2, according to a study.

A cancer researcher with a talent for leadership, Marks turned the Memorial Sloan Kettering Cancer Center into one of the world’s foremost oncology research institutions.

Contact tracing and genetic testing reveal how SARS-CoV-2 circulated among individuals for weeks, especially in the US, before being detected.

About one-quarter of the hundreds of genes on the inactivated X chromosome in XX cells manage to escape that silencing, at least some of the time.

When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.

The accumulation of zombie-like cells seems to accelerate aging and promote aging-related disease. Researchers are trying to figure out how.

Researchers find 380 amino acid substitutions between 2019-nCoV and severe acute respiratory syndrome (SARS)-related coronaviruses.

In the first clinical study of its kind in the US, researchers used CRISPR to modify CAR T cells to make them more potent against cancer, but the clinical benefits are unknown.

A mouse model of autism and postmortem brains of autistic individuals showed a lack of mature oligodendrocytes and less myelination than controls.

With more than 6,000 cases of the 2019-nCoV virus confirmed, researchers are hoping that studying the pathogen in the lab will help stop the outbreak.

Researchers are trying to figure out where it came from, whether it’s evolving, and just how big a threat it will be.

The Oxford researcher’s work on lipid and peptide antigens revealed key mechanisms in inflammation, immunotherapy, and vaccination, which are being pursued in clinical trial treatments.

A tool for identifying jumping gene insertions in DNA sequencing data turns up possible explanations for four patients’ rare developmental disorders.

A technique called Mendelian randomization is overturning the conclusions of observational studies in public health. But researchers question whether the method can overcome its fundamental limitations.

The modification of three babies’ genes by He Jiankui drew widespread criticism from scientists.

The animals lived longer and showed milder symptoms than untreated mice, although they didn’t survive as long as wildtype mice.

Trophoblasts, collected from the mother during a blood draw, can determine fetal genetic abnormalities currently diagnosed through amniocentesis or chorionic villi sampling.

The US Food and Drug Administration halts a study by Solid Biosciences after a patient experiences severe side effects following treatment.

A woman whose DNA suggested she’d develop early-onset dementia staved off cognitive decline for decades.