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image: Condensin Folds DNA Through Loop Extrusion

Condensin Folds DNA Through Loop Extrusion

By Diana Kwon | June 1, 2018

By observing the activity of a protein complex in real time, researchers have uncovered new evidence for a long-standing theory.

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image: Incomplete Immunity

Incomplete Immunity

By Jim Daley | June 1, 2018

By combining experimental data with computer models, researchers were able to predict a pathogen’s evolution toward more virulence.

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image: Productivity Paradox

Productivity Paradox

By Jim Daley | June 1, 2018

During the last ice age, there wasn’t much plant matter to eat on northern steppes, but herbivorous woolly mammoths were abundant. How did they survive?

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image: Big Data in 3 Dimensions

Big Data in 3 Dimensions

By Jim Daley | May 1, 2018

Viewing oncogenic mutations in 3-D showed that they cluster together on folded proteins.

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The flow of calcium and potassium ions keeps muscles contracting in the diaphragms of neonatal mice, but if a key protein receptor is missing, fatigue sets in more quickly.

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image: Copper Connections

Copper Connections

By Jim Daley | May 1, 2018

Researchers initially set out to investigate the relationship between copper homeostasis and the rare Menkes disease, but they also found links to Parkinson’s.

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Mice treated with an immunostimulant had better outcomes when researchers blocked the expression of TNFR2, a compound that helps tumors evade immune attack.

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In the presence of cytosolic DNA, cancer cells activate antiviral pathways that disguise them as immune cells.

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image: Mutant RAS Proteins Team Up for Oncogenicity

Mutant RAS Proteins Team Up for Oncogenicity

By Jim Daley | April 1, 2018

Mice with cancer whose KRAS proteins couldn’t link together had much better survival outcomes than those whose oncogenic mutant paired with wild-type KRAS.

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image: A Systematic Approach to Finding Unannotated Proteins

A Systematic Approach to Finding Unannotated Proteins

By Katarina Zimmer | March 1, 2018

A study suggests that there is more to the eukaryotic genome than was previously suspected.

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