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image: Big Data in 3 Dimensions

Big Data in 3 Dimensions

By Jim Daley | May 1, 2018

Viewing oncogenic mutations in 3-D showed that they cluster together on folded proteins.

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Mice treated with an immunostimulant had better outcomes when researchers blocked the expression of TNFR2, a compound that helps tumors evade immune attack.

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In the presence of cytosolic DNA, cancer cells activate antiviral pathways that disguise them as immune cells.

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image: Mutant RAS Proteins Team Up for Oncogenicity

Mutant RAS Proteins Team Up for Oncogenicity

By Jim Daley | April 1, 2018

Mice with cancer whose KRAS proteins couldn’t link together had much better survival outcomes than those whose oncogenic mutant paired with wild-type KRAS.

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In response to short DNA fragments, lymphocytes release mitochondrial DNA that helps trigger an immune response.

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A single receptor on natural killer cells recognizes an amino acid sequence conserved across Zika, dengue, and related pathogens.

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When peripheral nerves are severed, Schwann cells at the injury site begin to proliferate and exhibit stem cell-like gene expression patterns.

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image: Microglia Turnover in the Human Brain

Microglia Turnover in the Human Brain

By Shawna Williams | October 1, 2017

Researchers find that about a quarter of the immune cells are replaced every year.

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image: How Immune Receptors Got into Mouse Noses

How Immune Receptors Got into Mouse Noses

By Shawna Williams | September 1, 2017

A study traces proteins’ evolution from the immune to the olfactory system.

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image: Epigenetic Inheritance in Nematodes

Epigenetic Inheritance in Nematodes

By Catherine Offord | July 17, 2017

The memory of a temperature spike can persist for as many as 14 generations in C. elegans.

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