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image: Big Data in 3 Dimensions

Big Data in 3 Dimensions

By Jim Daley | May 1, 2018

Viewing oncogenic mutations in 3-D showed that they cluster together on folded proteins.

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Mice treated with an immunostimulant had better outcomes when researchers blocked the expression of TNFR2, a compound that helps tumors evade immune attack.

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In the presence of cytosolic DNA, cancer cells activate antiviral pathways that disguise them as immune cells.

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image: Mutant RAS Proteins Team Up for Oncogenicity

Mutant RAS Proteins Team Up for Oncogenicity

By Jim Daley | April 1, 2018

Mice with cancer whose KRAS proteins couldn’t link together had much better survival outcomes than those whose oncogenic mutant paired with wild-type KRAS.

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When peripheral nerves are severed, Schwann cells at the injury site begin to proliferate and exhibit stem cell-like gene expression patterns.

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image: Microglia Turnover in the Human Brain

Microglia Turnover in the Human Brain

By Shawna Williams | October 1, 2017

Researchers find that about a quarter of the immune cells are replaced every year.

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Pauses may help cells fine-tune gene expression.

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image: Researchers Identify Clue to Asymmetric Cell Division

Researchers Identify Clue to Asymmetric Cell Division

By Shawna Williams | September 1, 2017

Phosphorylation of a surface protein on endosomes is key to the organelles’ uneven distribution in daughter cells.

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Using single-cell RNA sequencing, scientists characterize new populations of dendritic cells and monocytes.

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The presence of similar light-emitting enzymes in the distantly related organisms lends new insight into bioluminescence evolution.

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