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image: Hearing Discrepancy Probed

Hearing Discrepancy Probed

By Amanda B. Keener | September 1, 2015

Common in vitro experiments have distorted the true mechanics of mammalian hair cell stereocilia.

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image: Inner Ear Undertakers

Inner Ear Undertakers

By Kerry Grens | September 1, 2015

Support cells in the inner ear respond differently to two drugs that kill hair cells.

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image: The Regenerators

The Regenerators

By Amanda B. Keener | September 1, 2015

A molecular signature makes it possible to trace the details of hair cell replacement in the mammalian inner ear.

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image: Signaling Resistance

Signaling Resistance

By Jenny Rood | April 1, 2015

Activating signaling pathways, rather than individual genes, reveals roles for both growth and dedifferentiation in establishing resistance to cancer treatments.

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image: Toggling Between Life and Death

Toggling Between Life and Death

By Ashley P. Taylor | April 1, 2015

In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.

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image: Growth Hormone Guidance

Growth Hormone Guidance

By Jenny Rood | March 1, 2015

Intact growth hormone signaling pathways are needed for methionine restriction to extend mouse lifespan.

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image: Long Live Collagen

Long Live Collagen

By Ashley P. Taylor | March 1, 2015

Increased collagen expression is a common feature of many different pathways to extended longevity in worms.

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image: Bouncing Back

Bouncing Back

By Ashley P. Taylor | February 1, 2015

In mice, a transcriptional regulator, β-catenin, activates a microRNA-processing pathway in the nucleus accumbens to promote resilience to social stress.

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image: Tangle Trigger

Tangle Trigger

By Jyoti Madhusoodanan | January 1, 2015

An enzyme that cleaves tau protein in acidic cellular conditions may trigger early events in Alzheimer’s disease.

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image: Mitochondria Munchers

Mitochondria Munchers

By Jyoti Madhusoodanan | November 1, 2014

Glial cells consume mitochondria released by neurons in the optic nerve.

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