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The Literature

» cell division, physiology, microbiology and cancer

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Mice treated with an immunostimulant had better outcomes when researchers blocked the expression of TNFR2, a compound that helps tumors evade immune attack.

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In the presence of cytosolic DNA, cancer cells activate antiviral pathways that disguise them as immune cells.

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image: Mutant RAS Proteins Team Up for Oncogenicity

Mutant RAS Proteins Team Up for Oncogenicity

By Jim Daley | April 1, 2018

Mice with cancer whose KRAS proteins couldn’t link together had much better survival outcomes than those whose oncogenic mutant paired with wild-type KRAS.

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When peripheral nerves are severed, Schwann cells at the injury site begin to proliferate and exhibit stem cell-like gene expression patterns.

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image: Microglia Turnover in the Human Brain

Microglia Turnover in the Human Brain

By Shawna Williams | October 1, 2017

Researchers find that about a quarter of the immune cells are replaced every year.

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image: Researchers Identify Clue to Asymmetric Cell Division

Researchers Identify Clue to Asymmetric Cell Division

By Shawna Williams | September 1, 2017

Phosphorylation of a surface protein on endosomes is key to the organelles’ uneven distribution in daughter cells.

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image: Bone Marrow Isn’t the Only Source of Platelets

Bone Marrow Isn’t the Only Source of Platelets

By Ashley P. Taylor | June 1, 2017

Scientists have estimated that about half of murine platelet production occurs in the lungs.

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image: Rare T Cells Fight Cancer

Rare T Cells Fight Cancer

By Jef Akst | May 1, 2017

A new approach to immunotherapy finds that the immune-cell clonotypes that come to the rescue start out at very low frequencies.

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Mice engineered to overproduce the organelles involved in cell division spontaneously develop malignancies.

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While studying the progression of healthy cells into cancerous ones, researchers discover a way to engraft human blood cells into animals.

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