Critic at Large

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Measuring PD-L1 levels was a great start. Now we need to quantify more protein biomarkers, assess the tumor mutational landscape, and examine immune cell signatures, too.

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image: Opinion: Improving FDA Evaluations Without Jeopardizing Safety and Efficacy

Opinion: Improving FDA Evaluations Without Jeopardizing Safety and Efficacy

By | February 1, 2017

What can be done to lower development costs and drug prices?

4 Comments

image: Opinion: An Ethical Code for Conferences

Opinion: An Ethical Code for Conferences

By | December 2, 2016

This fundamental form of scientific communication is threatened by modern recording technology and researchers who refuse to adhere to an age-old ethical code. 

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image: Getting Animal Research Right

Getting Animal Research Right

By | March 1, 2016

Regulatory and compliance expectations for animal-based research are demanding, while public and political scrutiny of animal research is rising.

2 Comments

image: Body, Heal Thyself

Body, Heal Thyself

By | September 1, 2015

Reviving a decades-old hypothesis of autoimmunity

8 Comments

image: Hurdles for Hearing Restoration

Hurdles for Hearing Restoration

By | September 1, 2015

Given the diverse cell types and complex structure of the human inner ear, will researchers ever be able to re-create it?

1 Comment

image: When Does a Smart Mouse Become Human?

When Does a Smart Mouse Become Human?

By | July 1, 2015

Ethical issues attend the creation of animal-human chimeras.

1 Comment

image: Control ALT, Delete Cancer

Control ALT, Delete Cancer

By , , and | April 1, 2015

Treating cancer by shutting down the alternative lengthening of telomeres (ALT) pathway

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image: The Challenges of Precision

The Challenges of Precision

By | April 1, 2015

Researchers face roadblocks to treating an individual patient’s cancer as a unique disease.

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image: Facing Down Emerging Viruses

Facing Down Emerging Viruses

By | February 1, 2015

A better knowledge of the pathogenesis of emerging zoonotic diseases is crucial if we want to prepare for “the next Ebola.”

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