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image: New Methods to Detect CRISPR Off-Target Mutations

New Methods to Detect CRISPR Off-Target Mutations

By Sandeep Ravindran | March 1, 2018

Researchers have developed a variety of techniques to detect when CRISPR misses the mark.

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image: Drugging the Disorderome

Drugging the Disorderome

By Amber Dance | October 1, 2017

Strategies for targeting intrinsically disordered proteins

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image: Pinpointing the Culprit

Pinpointing the Culprit

By Rachel Berkowitz | June 1, 2017

Identifying immune cell subsets with CyTOF

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image: A Selection of CRISPR Proof-of-Principle Studies

A Selection of CRISPR Proof-of-Principle Studies

By Kelly Rae Chi | March 1, 2017

Advice on how to deploy the latest techniques in your own lab

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image: Discovering Novel Antibiotics

Discovering Novel Antibiotics

By Sandeep Ravindran | February 1, 2017

Three methods identify and activate silent bacterial gene clusters to uncover new drugs

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image: Characterizing the Imprintome

Characterizing the Imprintome

By Amber Dance | January 1, 2017

Three techniques for identifying the collection of maternal and paternal genes silenced in offspring

3 Comments

image: Techniques for Assessing Genomic Copy Number Variations

Techniques for Assessing Genomic Copy Number Variations

By Sarah C.P. Williams | October 1, 2016

As the importance of genomic copy number variations for health and disease becomes clearer, researchers are creating new ways to detect these changes in the genome.

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image: Designing In Vitro Models of the Blood-Brain Barrier

Designing In Vitro Models of the Blood-Brain Barrier

By Jyoti Madhusoodanan | September 1, 2016

Choosing the right model, be it 3-D or 2-D, requires wading through varied cell sources, cell types, and cell culture conditions.

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Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.

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image: How to Build Bioinformatic Pipelines Using Galaxy

How to Build Bioinformatic Pipelines Using Galaxy

By Jeffrey M. Perkel | August 1, 2016

A point-and-click interface alternative to command-line tools that allows researchers to easily create, run, and troubleshoot serial sequence analyses

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