genetics & genomics, stem cells

Changes in gene expression also hint at how the brains of people with ASD develop differently from those of other people.

Brain organoids engineered to carry the genetic material could reveal how our brains are similar to and different from those of our closest relatives.

Michael Christman oversaw the organization’s well-known biobank and pioneered a personalized medicine initiative.

A byproduct of alcohol consumption causes mutations in the DNA of mouse blood stem cells, and some of the breaks are not repaired.

A combination gene-and-cell therapy has given a boy with a grievous skin disease a new lease on life, and has resolved a dermatology debate to boot.

Genomic analysis of an oak tree that lived during Napoleon’s time supports the idea that plants somehow avoid the accumulation of mutations in their stem cells.

A screen of human embryonic stem cell lines finds several that accumulated changes in the gene TP53, including aberrations commonly seen in cancer.

iPSCs created through the reprogramming of human somatic cells retain genomic marks of the donor’s age.

Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.

A remaining challenge in the study of human accelerated regions (HARs) is establishing their specific functions during development and other biological processes.

A set of international stem cell guidelines recommends that oversight committees at research institutions oversee all research on embryos.

Legal expert Henry Greely envisions a world in which advances in biotechnology obviate the need for sexual reproduction as we know it.

Elaine Fuchs has worked on adult stem cells since before they were so named, figuring out how multipotent epidermal cells renew or turn into skin or hair follicles.

An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.

A variation of the gene-editing technique can more precisely and efficiently downregulate the expression of target genes than traditional CRISPR/Cas9.

Researchers devise a technique for creating gametes from murine embryonic stem cells.

There’s more to inheritance than genes.

An upcoming clinical trial aims to correct for a disease of fragile bones in affected babies before they are born.

From DNA damage to cellular miscommunication, aging is a mysterious and multifarious process.