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Mass Spectrometry Applications for Proteomics
Jeffrey Perkel | Aug 19, 2001 | 10+ min read
Click to view the PDF file: Proteomic Mass Spectrometry Equipment Courtesy of CiphergenCiphergen's SELDI process, a MALDI variant that includes a surface-based enrichment step Early in the twentieth century, scientists puzzled over the observation that certain elements that were otherwise physically indistinguishable from each other nevertheless exhibited different radioactive decay characteristics. These elements would ultimately come to be known as isotopes, but at the time this concept was
Protein Microarrays Mature
Aileen Constans | Aug 1, 2004 | 9 min read
THE 4-1-1 ON PWG:Courtesy of ZeptosensPlanar waveguide (PWG) technology (right) has the advantage over conventional epifluorescence excitation (left) for surface-confined assays in that only surface-bound fluorphores respond to the excitation source. Labels that are located more than about 400-nm from the surface do not fluoresce. Zeptosens uses PWG technology to enhance sensitivity of its protein arrays.While not as ubiquitous as their DNA counterparts, pro tein arrays are starting to hold thei
Antibody Microarrays Highlight Enzyme Activity
Charles Choi | Feb 13, 2005 | 2 min read
When it comes to enzymes, protein abundance does not necessarily translate into protein activity: Post-translational modifications such as phosphorylation can dramatically alter enzyme function.
Quantitating Glycans for Biomarker Discovery
Amanda Keener | Aug 27, 2017 | 8 min read
Techniques for comparing the relative abundances of glycans and glycoproteins in clinical samples
A Comprehensive Guide to Proteomics
An Introductory Guide to Proteomics
Sejal Davla, PhD | Jan 16, 2023 | 5 min read
Deconstructing concepts, approaches, and data analysis in proteomics workflows.  
2017 Top 10 Innovations
The Scientist | Dec 1, 2017 | 10+ min read
From single-cell analysis to whole-genome sequencing, this year's best new products shine on many levels.
Tackling the Challenges Involved with Protein Biomarkers
The Scientist Marketing Team | Jul 5, 2012 | 2 min read
Check out a discussion of the hottest tips and trends in the emerging field of protein biomarkers.
Reducing Risks, Maximizing Impact with Cancer Biomarkers
Athos Gianella-Borradori | Mar 14, 2004 | 3 min read
Brad FitzpatrickBiomarkers measure drug-induced changes in a patient's blood or tissue. Such changes can confirm drug activity and thereby help select patients more likely to respond to treatment. These biochemicals are revolutionizing cancer drug development.It's a revolution sorely needed. A recent Nature Medicine story described 2003 as filled "with hype and hope for cancer drugs ... [The year] saw no shortage of cancer headlines ... But recent successes have not been unequivocal, and emphasi
What Kind of Mass Spec User are You?
Jeffrey M. Perkel | Feb 1, 2007 | 5 min read
Whether studying proteins, nucleic acids, or small molecules, there's an ideal configuration for everyone.
2019 Top 10 Innovations
The Scientist | Dec 1, 2019 | 10+ min read
From a mass photometer to improved breath biopsy probes, these new products are poised for scientific success.

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