neuroscience, disease & medicine, Alzheimer's Disease

Patients who received the drug fared better cognitively and functionally than those taking placebo, but still experienced losses in performance.

Manipulating the production of new neurons can improve cognition in animal models of the disease, raising the possibility that figuring out a way for humans to make more neurons could make a difference for people with dementia.

The variant causes a buildup of BACE1 protein in axons in cultured neurons and mice. Researchers say it might be time to rethink failed trials that inhibit BACE1 to treat the neurodegenerative disease.

The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.

New studies show that elevated levels of a form of tau called p-tau217 can accurately distinguish Alzheimer’s disease from other forms of dementia, and perhaps even predict it.

Digital biomarkers of cognitive decline could alert us to the early stages of dementia before irreversible damage occurs.

After an accident as a teenager, he developed the disorder. He then studied the brain to better understand his own seizures, and now plans to sail around the world to show others with the condition how to push their limits.

While the findings contradict previous studies that have linked human herpesvirus 6 to the neurodegenerative disease, they do not eliminate the possibility of a relationship.

A look at some of the circulating molecules that may indicate various Alzheimer’s pathologies and serve as the bases of noninvasive tests for the disease.

Researchers hope circulating biomarkers will enable earlier detection and better monitoring of the neurodegenerative disorder—and perhaps help usher in new treatments.

Oligomannate, recently approved in China, is being met with some skepticism from researchers.

Contaminants in the atmosphere appear to have harmful effects on neurodevelopment and cognitive function.

A growing body of evidence supports the theory that neural hyperactivity and hyperconnectivity precede the pathological changes that lead to neurodegeneration.

Patients who suffer a traumatic brain injury may exhibit abnormally abundant tau protein many years later, a new in vivo imaging technique reveals.

Mutations within the MS4A gene cluster have been linked to changes in protein levels that affect disease risk.

Despite doubts last year about human adult neurogenesis, a study shows even 80-year-olds develop new cells in the hippocampus, but such growth is diminished in patients with Alzheimer’s disease.

Exposing mice to an hour of 40-hertz stimuli every day for a week reduced levels of amyloid-β plaques and tau protein, and improved cognition.

The protein expression data, which are freely available online, could help identify new drug targets for the disease.

The observation could pave the way for a blood test to predict disease progression in people with a genetic predisposition to developing the neurodegenerative disorder.

Studies have demonstrated that magnetic and electrical currents can enhance memory in human subjects, but the technology is not yet ready for prime time.