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Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Contributors
Beth Marie Mole | Dec 1, 2012 | 3 min read
Meet some of the people featured in the December 2012 issue of The Scientist.
Weathering Hantavirus: Ecological Monitoring Provides Predictive Model
Steve Bunk | Jul 4, 1999 | 7 min read
Photo: Steve Bunk Dave Tinnin, field research associate in the University of New Mexico's biology department, takes blood samples and measurements of rodents caught on the research station grounds. At the end of a freeway exit near Soccoro, N.M., the hairpin turn onto a gravel road is marked by a sign that warns, "Wrong Way." But it isn't the wrong way if you want to reach the University of New Mexico's (UNM) long-term ecological research (LTER) station. The sign's subterfuge is the first indi
Research Notes
Nadia Halim | Sep 3, 2000 | 5 min read
Stopping Ebola in Its Tracks Richard Preston brought the threat of emerging infectious diseases to the consciousness of his readers in The Hot Zone. The book graphically describes how the Ebola virus causes massive internal bleeding, which kills up to 90 percent of the people it infects. Now National Institutes of Health scientists are making promising advances to stop disease spread. Researchers have identified a viral protein that destroys endothelial cells, the cells that line the blood vess
Biological Terrorism
Jennifer Fisher Wilson | Nov 11, 2001 | 8 min read
One warning came in black-and-white in 1993: A U.S. Congressional Office of Technology Assessment report projected that releasing 100 kilograms of aerosolized anthrax spores upwind of the U.S. capital could kill between 130,000 and 3 million people-a lethality at least matching that of a hydrogen bomb. Last year, a U.S. Justice Department exercise revealed that discharging pneumonic plague in Denver could create 3,700 or more cases, with an estimated 950 or more deaths within a week.1 Then, acco
Changing Oceans Breed Disease
Christie Wilcox, PhD | Jul 1, 2016 | 10+ min read
In the planet’s warming and acidifying oceans, species from corals to lobsters and fish are succumbing to pathogenic infection.
Notebook
Paul Smaglik | Nov 21, 1999 | 6 min read
Contents Pivotal pump Leptin limbo Clue to obesity Biotech Web site Helping hand Mapping malaria UCSD - Salk Program in Molecular Medicine HEART FAILURE RESCUE: A cross section of a mouse genetically engineered to develop heart failure (left) shows enlarged heart chambers and thin walls that are typical of the condition. A cross section from the same strain of mouse, but with the phospholamban gene (PLB) also missing, appears normal. PIVOTAL PUMP A biochemical calcium pump and the gene that con
The Proteasome: A Powerful Target for Manipulating Protein Levels
John Hines and Craig M. Crews | May 1, 2017 | 10+ min read
The proteasome’s ability to target and degrade specific proteins is proving useful to researchers studying protein function or developing treatments for diseases.
Illuminating Behaviors
Douglas Steinberg | Jun 1, 2003 | 6 min read
Courtesy of Genevieve Anderson If not for Nobel laureates Thomas Hunt Morgan, Eric R. Kandel, and Sydney Brenner, the notion of a general behavioral model might seem odd. Behaviors, after all, are determined by an animal's evolutionary history and ecological niche. They are often idiosyncratic, shared in detail only by closely related species. But, thanks to Morgan's research in the early 20th century, and Kandel's and Brenner's work over the past 35 years, the fly Drosophila melanogaster, t
Death to Biologists
Richard Gallagher | Jul 18, 2004 | 2 min read
"In the last analysis it is our conception of death which decides our answers to all the questions life puts to us."- Dag HammarskjoldDeath and dying are of fundamental importance to biologists and medical doctors. Yet, their study is a backwater of research that deserves far more attention. In a PubMed search, "aging" papers outnumber "dying" papers by 10 to 1, and "sex" outnumbers "dying" by 20 to 1.Death and dying are not being taught, either. Of the three top-selling human biology textbooks,

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