Modus Operandi

A device for piercing individual holes in cell membranes allows vector-free DNA delivery while maintaining cell viability.

Modified gene editing machinery enables targeted disruptions of mitochondrial genes in rice and rapeseed plants.

Using reverse genetics, researchers create antibodies to reel in previously uncultured bacteria.

DNA-responsive polymer gels used for releasing drugs, encapsulating cells, and much more now have greater adaptability thanks to the Cas12a nuclease.

Recruiting an epigenetic instigator of centromere formation into large segments of cloned DNA facilitates their transformation into artificial chromosomes.

An implantable wireless device with microfluidic and optical components allows manipulation of individual nerve fibers in mice’s extremities.

DNA-coated gold nanorods enable cells to be activated by light without genetic manipulation.

A CRISPR-based electronic sensor flags target DNA sequences at high speed.

Optimized tweezers enable precise 3-D manipulations of a cell’s organelles.

Artificially intelligent software has human-like ability to analyze host-pathogen interactions in microscopy images.

A prototype in-vein device would collect toxic medications before they reach healthy tissues.

A microneedle-containing skin patch offers researchers a noninvasive way to survey immune responses in mice.

Adenine editing enzymes have been adapted for use in plants.

Researchers repurpose the CRISPR machinery to turn whole classes of transposable elements on or off.

Acoustic forces can be used to differentiate adherent from non-adherent cells.

Ultraflexible mesh electrodes monitor the intact, functioning eyes of awake animals.

STARmap enables simultaneous analysis of multiple RNAs in intact, bulky samples.

Researchers identify a handy tool for tinkering with the versatile vesicles.

Tagging proteins with GFP-grabbing nanobodies enables instant tracking of the proteins’ dynamics in live cells.