techniques, methods

Out of 25,000 features originally detected by metabolic profiling of E. coli, fewer than 1,000 represent unique metabolites, a study finds.

A study finds the so-called DREADD method of manipulating neurons using a drug called CNO actually works via clozapine.

In a first, scientists reanimate the fish using embedded gold nanoparticles that heat up cells by absorbing laser light.

A new method stimulates B cells to make human antigen-specific antibodies, obviating the need for vaccinating blood donors or hunting for rare B cells.

To improve the resolution of biological samples at the cellular level, researchers inflate tissues with “swellable polymers” so that they’re easier to see under the microscope.    

Researchers develop a method that combines the strengths of shotgun metagenomics and single-cell genome sequencing in a microfluidics-based platform.

Current can guide implanted cells away from rats’ noses toward a region deep in their brains.

A study of off-target effects that sparked fear among investors of genome-editing companies receives methodological criticisms.

These engineered “cells” were made from the secretions and membranes of human mesenchymal stem cells.

See researchers' recipe for synthetic mesenchymal stem cells, which showed cardiac regenerative potential in mice.

Genetically engineered "disco bacteria" sense and respond to different colors of light, creating both stunning art in the culture dish and new possibilities for synthetic biology.

Researchers identify transcription factors and environmental conditions necessary to reprogram human and mouse cells into cells that function like hematopoietic stem cells.

A heat block, a truck battery, and a novel RNA amplification assay make for in-the-field surveillance of the virus.

Incorporating light-controlled dimerization domains into kinases provides tight regulation of these enzymes.

Custom-designed kinases have built-in switches that act as gatekeepers for the enzymes' active sites.

CLARITY made mouse bones transparent while preserving fluorescent labels so researchers could visualize tagged osteoprogenitors.

A double-expansion technique embeds brain tissue in the absorbent material of diapers to stretch out cells for easier visualization.

New monoclonal antibodies kill both cancer-promoting immunosuppressive cells and tumor cells in culture.

An experimental technique removes T cells that aid in vitro tumor growth.

Scientists combine CRISPR gene editing with single-cell sequencing for genotype-phenotype screens.