genetics & genomics, methods

Emmanuelle Charpentier and Jennifer Doudna reprogrammed the bacterial immune response into one of the most popular tools for genetics and molecular biology.

Organisms with unusual genomes are helping scientists investigate gene regulation, evolution, and development.

Two studies find the genome-editing technique works best when cells have a faulty DNA-damage response that’s frequently present in cancers.  

The use of underperforming computational tools is a major offender in science’s reproducibility crisis—and there’s growing momentum to avoid it.

Researchers use gold nanoparticles to deliver CRISPR-Cas9 and correct a point mutation in a mouse model of Duchenne muscular dystrophy. 

In a first, scientists reanimate the fish using embedded gold nanoparticles that heat up cells by absorbing laser light.

Researchers develop a method that combines the strengths of shotgun metagenomics and single-cell genome sequencing in a microfluidics-based platform.

A study of off-target effects that sparked fear among investors of genome-editing companies receives methodological criticisms.

Scientists combine CRISPR gene editing with single-cell sequencing for genotype-phenotype screens.

See how two new methods track responses to unique genetic manipulations in numerous individual cells in parallel.

A test tube-based genome-labeling technique has been brought under the microscope.

Tweaks to a transformation protocol in 1986 cemented the little plant's mighty role in plant genetics research.

Researchers design a Cas9 enzyme that cuts DNA only in the presence of particular drug.

Researchers have designed a screen to find unique molecules, called riboswitches, that determine whether transcription will proceed.

A versatile modular strategy for detecting small molecules in eukaryotes

Tailored combinations of a reporter and a ligand-binding domain allow for sensing just about any molecule of interest.

Modifications to the DNA-slicing program allow for monitoring the movement of messenger RNA.

Scientists perform plant-genome modifications on crops without using plasmids.

A challenge to the first CRISPR patent just got teeth.