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Jeffrey Perkel | Apr 29, 2001 | 2 min read
Antigen-specific T lymphocytes must be quantified in order to gauge the quality of an immune response. Typically this is accomplished using cytotoxicity assays or limiting dilution analysis (LDA), but these techniques are lengthy and provide indirect quantitation. Also, LDA cannot count nonproliferative cells. In 1996, Stanford University's Mark Davis developed an alternative strategy that overcomes these problems.1 Davis generated phycoerythrin-conjugated tetramers of human lymphocyte antigen (
Top 7 in Immunology
Edyta Zielinska | Aug 2, 2011 | 3 min read
A snapshot of the most highly ranked articles in microbiology and related areas, from Faculty of 1000
A white lab mouse peers over the wall of a sprawling maze
Bacterial Metabolite May Regulate Cognition in Mice
Sophie Fessl, PhD | Jun 3, 2022 | 3 min read
Microbes in the gut influence the death of support cells in the brain by producing isoamylamine, a study suggests.
Cancer cell
Interrogating the Complexities of the Tumor Microenvironment
Alison Halliday, PhD, Technology Networks | May 19, 2023 | 5 min read
Gaining a better understanding of the dynamic and reciprocal interactions between cancer cells and the tumor microenvironment is essential for improving patient diagnosis and treatment.
bacteria inside a biofilm
How Bacterial Communities Divvy up Duties
Holly Barker, PhD | Jun 1, 2023 | 10+ min read
Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics.
illustration of neurons in blue with synapses lighting up
Gut Molecule Linked to Decreased Myelination in Mouse Brains
Angie Voyles Askham, Spectrum | Feb 17, 2022 | 4 min read
A study shows that a molecule produced by intestinal microbes can enter the brain and that its presence is also associated with altered brain connectivity.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
T regulatory cell in red sandwiching an antigen presenting cell in blue
Gut Bacteria Help T Cells Heal Muscle: Study
Natalia Mesa, PhD | Mar 14, 2023 | 4 min read
Regulatory T cells in the colon travel to muscles to promote wound healing in mice, raising questions about how antibiotics may impact injury recovery.
A silver tree showing roots and branches in a circle on a blue background.
Onward and Upward!
Kristie Nybo, PhD | Sep 8, 2023 | 9 min read
At The Scientist, we are strengthening our roots while reaching for the sky.
Photo of Ankara Jain in his lab
Ankur Jain Explores RNA Aggregations in Neurodegenerative Disease
Hannah Thomasy, PhD | Oct 3, 2022 | 3 min read
The MIT biologist studies how RNA molecules self-assemble and the role these accumulations may play in diseases such as ALS and Huntington’s.

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