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image: How the Pediatric Laws Work

How the Pediatric Laws Work

By Bob Grant | March 1, 2012

The Pediatric Research Equity Act (PREA) of 2003 requires that companies developing new drugs that could be used to treat a condition in children perform clinical trials in kids before winning FDA approval. 

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image: Suspected Effects of Vitamin D

Suspected Effects of Vitamin D

By Amy Maxmen | March 1, 2012

Vitamin D has a variety of actions in the body. It binds to the vitamin D receptor (VDR), which then binds to the retinoid X receptor (RXR) and activates the expression of numerous genes. 

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image: Calcium and the Pancreas

Calcium and the Pancreas

By Ole H. Petersen, Oleg V. Gerasimenko, and Julia V. Gerasimenko | February 1, 2012

Normal pancreatic function depends on the precise flow of calcium within and into the acinar cells of the organ. 

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image: Inflammation, Pain, and Resolvins

Inflammation, Pain, and Resolvins

By Claudia Sommer and Frank Birklein | January 1, 2012

Not all inflammation leads to pain. Despite widespread infection followed by fever, colds rarely cause pain. But when some cytokines and certain immune cells are active near pain-sensing nerves, they trigger receptors that convey pain sensations to the brain.

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image: Swallowing the Surgeon

Swallowing the Surgeon

By Erica Westly | October 1, 2011

In fewer than 15 years, nanomedicine has gone from fantasy to reality.

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image: OPSINS: Tools of the trade

OPSINS: Tools of the trade

By Edward S. Boyden | July 1, 2011

The optogenetic toolset is composed of genetically encoded molecules that, when targeted to specific neurons in the brain, enable the electrical activity of those neurons to be driven or silenced by light. 

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image: Where Cancer and Inflammation Intersect

Where Cancer and Inflammation Intersect

By Giorgio Trinchieri | April 1, 2011

Recent clinical trials have reignited the interest in simple anti-inflammatory drugs like aspirin for controlling the inflammation associated with cancer. 

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image: Stress and Inflammation

Stress and Inflammation

By Christina M. Warboys, Narges Amini, Amalia de Luca, and Paul C. Evans | February 1, 2011

Stress and inflammation Cardiovascular disease, including coronary artery disease and stroke, is the single greatest cause of death worldwide and is a major burden on health services and society. 

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image: Death or Damage of Dopamine Neurons

Death or Damage of Dopamine Neurons

By Bobby Thomas and M. Flint Beal | February 1, 2011

The hallmark pathology of Parkinson’s disease is the damage and death of dopamine producing neurons in the brain. 

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