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image: Ubiquitin Chains in Action

Ubiquitin Chains in Action

By Keith D. Wilkinson and David Fushman | July 1, 2012

Present in every tissue of the body, ubiquitin appears to be involved in a dizzying array of functions, from cell cycle and division to organelle and ribosome biogenesis, as well as the response to viral infection. The protein plays at least two role

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image: Ubiquitin basics

Ubiquitin basics

By Keith D. Wilkinson and David Fushman | July 1, 2012

Despite its discovery as a protein that seems to show up everywhere, at least in eukaryotic cells, researchers are only beginning to scratch the surface of all of the cellular functions involving ubiquitin. 

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image: Designing Transition-State Inhibitors

Designing Transition-State Inhibitors

By Vern L. Schramm | May 1, 2012

A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor and more strongly than most, preventing enzymatic activity. 

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