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tag neurodegeneration physiology cell molecular biology cancer

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
Microfluidics: Biology’s Liquid Revolution
Laura Tran, PhD | Feb 26, 2024 | 8 min read
Microfluidic systems redefined biology by providing platforms that handle small fluid volumes, catalyzing advancements in cellular and molecular studies.
Green and red fluorescent proteins in a zebrafish outline the animal’s vasculature in red and lymphatic system in green in a fluorescent image. Where the two overlap along the bottom of the animal is yellow.
Serendipity, Happenstance, and Luck: The Making of a Molecular Tool
Shelby Bradford, PhD | Dec 4, 2023 | 10+ min read
The common fluorescent marker GFP traveled a long road to take its popular place in molecular biology today.
Lasker Award winner Piet Borst sits at his desk.
A Journey With Metabolism, Parasites, and Cancer
Laura Tran, PhD | Sep 21, 2023 | 7 min read
Piet Borst led stellar work on cell organelles, trypanosomes, and cancer drug resistance during the golden age of biology.
Molecular Biology
The Scientist Staff | Jul 5, 1992 | 1 min read
S.J. Baker, S. Markowitz, E.R. Fearon, J.K.V. Willson, B. Vogelstein, "Suppression of human colorectal carcinoma cell growth by wild- type p53,"Science, 249:912-15, 1990. S.J. Baker, A.C. Preisinger, J.M. Jessup, et al., "p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis," Cancer Research, 50:7717-22, 1990. Bert Vogelstein (Johns Hopkins Oncology Center, Baltimore, Md.): "Cancer represents not one disease but hundreds. Accordingly,
A close up of several modular puzzle pieces.
Making Connections: Click Chemistry and Bioorthogonal Chemistry
Deanna MacNeil, PhD | Feb 13, 2024 | 5 min read
Simple, quick, and modular reactions allow researchers to create useful molecular structures from a wide range of substrates.
Keeping Kidneys Healthy with a Hand from AI
Aparna Nathan, PhD | Dec 11, 2023 | 3 min read
Researchers found new mechanisms and drug targets for cystinosis.
Cell Biology
The Scientist Staff | Oct 25, 1992 | 1 min read
J. Martin, T. Langer, R. Boteva, A. Schramel, A.L. Horwich, F.-U. Hartl, "Chaperonin-mediated protein folding at the surface of groEL through a `molten globule'-like intermediate," Nature, 352:36-42, 1991. F.-Ulrich Hartl (Memorial Sloan Kettering Cancer Center, New York): "Molecular chaperones, proteins that help other proteins to fold, have emerged over recent years as an important topic of research in biology. While their physiological significance has been established through a combination
Black and gold sketch of Katalin Karikó and Drew Weissman.
Nobel Prize for mRNA Vaccines
Danielle Gerhard, PhD | Oct 2, 2023 | 5 min read
Katalin Karikó and Drew Weissman received this year’s Physiology or Medicine award for their work on RNA biology and mRNA-based vaccines.

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