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image: Immune Influence

Immune Influence

By Kate Yandell | April 1, 2016

In recent years, research has demonstrated that microbes living in and on the mammalian body can affect cancer risk, as well as responses to cancer treatment.


image: Metabolic Reprogramming

Metabolic Reprogramming

By Kivanç Birsoy and David M. Sabatini | April 1, 2016

How cancer cells fuel their rapid growth


image: Under Pressure

Under Pressure

By Lance L. Munn and Rakesh K. Jain | April 1, 2016

The causes and consequences of physical forces in the tumor microenvironment


image: A Complex Disorder

A Complex Disorder

By Stephen D. Hursting, Ciara H. O’Flanagan, and Laura W. Bowers | November 1, 2015

Factors that likely contribute to obesity include disruptions to intercellular signaling, increased inflammation, and changes to the gut microbiome.  


image: Not Immune to Fat

Not Immune to Fat

By Kate Yandell | November 1, 2015

The effect of a high-fat diet on murine T cells


image: Ubiquitin Chains in Action

Ubiquitin Chains in Action

By Keith D. Wilkinson and David Fushman | July 1, 2012

Present in every tissue of the body, ubiquitin appears to be involved in a dizzying array of functions, from cell cycle and division to organelle and ribosome biogenesis, as well as the response to viral infection. The protein plays at least two role


image: Telomere Basics

Telomere Basics

By Rodrigo Calado and Neal Young | May 1, 2012

Telomeres are repetitive, noncoding sequences that cap the ends of linear chromosomes. They consist of hexameric nucleotide sequences (TTAGGG in humans) repeated hundreds to thousands of times. 


image: Designing Transition-State Inhibitors

Designing Transition-State Inhibitors

By Vern L. Schramm | May 1, 2012

A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor and more strongly than most, preventing enzymatic activity. 


image: Suspected Effects of Vitamin D

Suspected Effects of Vitamin D

By Amy Maxmen | March 1, 2012

Vitamin D has a variety of actions in the body. It binds to the vitamin D receptor (VDR), which then binds to the retinoid X receptor (RXR) and activates the expression of numerous genes. 


image: Inflammation, Pain, and Resolvins

Inflammation, Pain, and Resolvins

By Claudia Sommer and Frank Birklein | January 1, 2012

Not all inflammation leads to pain. Despite widespread infection followed by fever, colds rarely cause pain. But when some cytokines and certain immune cells are active near pain-sensing nerves, they trigger receptors that convey pain sensations to the brain.


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