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image: Calcium and the Pancreas

Calcium and the Pancreas

By Ole H. Petersen, Oleg V. Gerasimenko, and Julia V. Gerasimenko | February 1, 2012

Normal pancreatic function depends on the precise flow of calcium within and into the acinar cells of the organ. 

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image: How Autophagy Works

How Autophagy Works

By Muriel Mari, Sharon A. Tooze, and Fulvio Reggiori | February 1, 2012

There are five steps of autophagosome biogenesis: induction, expansion, vesicle completion, fusion, and cargo degradation. 

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image: Inflammation, Pain, and Resolvins

Inflammation, Pain, and Resolvins

By Claudia Sommer and Frank Birklein | January 1, 2012

Not all inflammation leads to pain. Despite widespread infection followed by fever, colds rarely cause pain. But when some cytokines and certain immune cells are active near pain-sensing nerves, they trigger receptors that convey pain sensations to the brain.

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image: Taste in the Mouth, Gut, and Airways

Taste in the Mouth, Gut, and Airways

By Thomas E. Finger and Sue C. Kinnamon | December 1, 2011

The tongue may be the epicenter of taste sensation, but taste receptors are scattered throughout the digestive and respiratory tracts.

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image: Swallowing the Surgeon

Swallowing the Surgeon

By Erica Westly | October 1, 2011

In fewer than 15 years, nanomedicine has gone from fantasy to reality.

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image: Helpful Bacterial Metabolites

Helpful Bacterial Metabolites

By Michelle G. Rooks and Wendy S. Garrett | August 1, 2011

While gut microbiota appear to have both positive and negative impacts on our  health, in the guts of healthy, lean individuals, the good outweighs the bad.  

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image: Harmful Bacterial Metabolites

Harmful Bacterial Metabolites

By Michelle G. Rooks and Wendy S. Garrett | August 1, 2011

Gut bacteria that feed on healthy food appear to amplify the nutritional benefits of those foods. However, they also appear to amplify the undesirable effects of unhealthy food. 

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image: OPSINS: Tools of the trade

OPSINS: Tools of the trade

By Edward S. Boyden | July 1, 2011

The optogenetic toolset is composed of genetically encoded molecules that, when targeted to specific neurons in the brain, enable the electrical activity of those neurons to be driven or silenced by light. 

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image: Exosome Basics

Exosome Basics

By Clotilde Théry | July 1, 2011

Exosomes are small membrane vesicles secreted by most cell types. Internal vesicles form by the inward budding of cellular compartments known as multivesicular endosomes (MVE). 

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image: Where Cancer and Inflammation Intersect

Where Cancer and Inflammation Intersect

By Giorgio Trinchieri | April 1, 2011

Recent clinical trials have reignited the interest in simple anti-inflammatory drugs like aspirin for controlling the inflammation associated with cancer. 

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