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» inflammation, biochemistry and neuroscience

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image: Not Immune to Fat

Not Immune to Fat

By Kate Yandell | November 1, 2015

The effect of a high-fat diet on murine T cells

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image: Neurogenesis in the Mammalian Brain

Neurogenesis in the Mammalian Brain

By Jef Akst | October 1, 2015

Neuron nurseries in the adult brains of rodents and humans appear to influence cognitive function.

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image: Sex on the Brain

Sex on the Brain

By Margaret M. McCarthy | October 1, 2015

Masculinization of the developing rodent brain leads to significant structural differences between the two sexes.

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image: Closing the Loop

Closing the Loop

By Amanda B. Keener | October 1, 2015

Micromanaging neuronal behavior with optogenetics

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image: Sugar Coma Model

Sugar Coma Model

By Ashley P. Taylor | October 1, 2015

How glucose fires up sleep-inducing neurons

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image: Mapping Corti

Mapping Corti

By Ruth Williams | September 3, 2015

The inner ear organ, from macro to micro

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image: Insulin's Role in Body and Brain

Insulin's Role in Body and Brain

By Oksana Kaidanovich-Beilin, Danielle S. Cha, and Roger S. McIntyre | December 6, 2012

Insulin, long recognized as a primary regulator of blood glucose, is now also understood to play key roles in neuroplasticity, neuromodulation, and neurotrophism.

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image: Ubiquitin Chains in Action

Ubiquitin Chains in Action

By Keith D. Wilkinson and David Fushman | July 1, 2012

Present in every tissue of the body, ubiquitin appears to be involved in a dizzying array of functions, from cell cycle and division to organelle and ribosome biogenesis, as well as the response to viral infection. The protein plays at least two role

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image: Ubiquitin basics

Ubiquitin basics

By Keith D. Wilkinson and David Fushman | July 1, 2012

Despite its discovery as a protein that seems to show up everywhere, at least in eukaryotic cells, researchers are only beginning to scratch the surface of all of the cellular functions involving ubiquitin. 

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image: Designing Transition-State Inhibitors

Designing Transition-State Inhibitors

By Vern L. Schramm | May 1, 2012

A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor and more strongly than most, preventing enzymatic activity. 

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