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image: Infographic: A Painful Pathway

Infographic: A Painful Pathway

By Catherine Offord | January 1, 2018

Since the mid-2000s, the voltage-gated sodium channel NaV1.7 has emerged as a promising target for a new class of analgesics.


image: Infographic: Breaking into the Brain

Infographic: Breaking into the Brain

By Amanda B. Keener | November 1, 2017

The blood-brain barrier is a collection of specialized cells and proteins that control the movement of molecules from the blood to the central nervous system.


image: Infographic: Proteasome Basics

Infographic: Proteasome Basics

By John Hines and Craig M. Crews | May 1, 2017

The structure and function of the cell's protein-degrading machine


image: Infographic: The Cost of Drug Development

Infographic: The Cost of Drug Development

By John D. Loike and Jennifer Miller | February 1, 2017

Expensive clinical trials and few drug approvals can drive up drug prices for consumers.


image: Infographic: Repurposing Strategies

Infographic: Repurposing Strategies

By Anna Azvolinsky | January 1, 2017

Novel uses for existing and failed drugs may save companies time and money in bringing new therapeutics to market.


image: Delivering New Genes

Delivering New Genes

By Jef Akst | June 1, 2012

Gene therapies typically involve the introduction of genetic material into target cells to replace or supplement an existing, usually dysfunctional, gene. 


image: How Drugs Interact with a Baby’s Parts

How Drugs Interact with a Baby’s Parts

By Edyta Zielinska | March 1, 2012

A lot changes in a child’s body over the course of development, and not all changes occur linearly: gene expression can fluctuate, and organs can perform different functions on the way to their final purpose in the body. Here are some of the key deve


image: How the Pediatric Laws Work

How the Pediatric Laws Work

By Bob Grant | March 1, 2012

The Pediatric Research Equity Act (PREA) of 2003 requires that companies developing new drugs that could be used to treat a condition in children perform clinical trials in kids before winning FDA approval. 


image: Calcium and the Pancreas

Calcium and the Pancreas

By Ole H. Petersen, Oleg V. Gerasimenko, and Julia V. Gerasimenko | February 1, 2012

Normal pancreatic function depends on the precise flow of calcium within and into the acinar cells of the organ. 


image: Stress and Inflammation

Stress and Inflammation

By Christina M. Warboys, Narges Amini, Amalia de Luca, and Paul C. Evans | February 1, 2011

Stress and inflammation Cardiovascular disease, including coronary artery disease and stroke, is the single greatest cause of death worldwide and is a major burden on health services and society. 


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