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Infographic: How Some X-Chromosome Genes Escape Inactivation
Infographic: How Some X-Chromosome Genes Escape Inactivation
About one-quarter of the hundreds of genes on the inactivated X chromosome in XX cells manage to escape that silencing, at least some of the time.
Infographic: How Some X-Chromosome Genes Escape Inactivation
Infographic: How Some X-Chromosome Genes Escape Inactivation

About one-quarter of the hundreds of genes on the inactivated X chromosome in XX cells manage to escape that silencing, at least some of the time.

About one-quarter of the hundreds of genes on the inactivated X chromosome in XX cells manage to escape that silencing, at least some of the time.

genetics & genomics, cell & molecular biology

Researchers Discover the Largest Virus in the Oceans Yet
Kerry Grens | Mar 1, 2020 | 4 min read
The ChoanoVirus genome codes for rhodopsin, perhaps giving its choanoflagellate host extra energy-harvesting capabilities.
Genes that Escape Silencing on the Second X Chromosome May Drive Disease
Amber Dance | Mar 1, 2020 | 10+ min read
When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.
Infographic: How Does Cell Senescence Drive Aging and Disease?
Katarina Zimmer | Mar 1, 2020 | 4 min read
The accumulation of zombie-like cells seems to accelerate aging and promote aging-related disease. Researchers are trying to figure out how.
Killifish Embryos Pause Development Without Consequence: Study
Lisa Winter | Feb 21, 2020 | 3 min read
Contrary to popular thinking, the period of arrested development is an active state of maintaining muscle integrity.
Inadequate Myelination of Neurons Tied to Autism: Study
Lisa Winter | Feb 4, 2020 | 2 min read
A mouse model of autism and postmortem brains of autistic individuals showed a lack of mature oligodendrocytes and less myelination than controls.
Image of the Day: Regenerating Worms
Amy Schleunes | Feb 3, 2020 | 1 min read
Planarian flatworms grow to double their normal size when scientists inhibit a gene that suppresses growth.
Engineered Microbe in Bees’ Guts Fends off Deadly Varroa Mite
Lisa Winter | Jan 31, 2020 | 2 min read
The genetically modified bacteria spark an RNAi response in the parasite that leads to self-destruction—and perhaps a path to combatting colony collapse disorder.
a baby's hand cradled by an adult hand
Lottery Underway for Rare Muscle-Wasting Disease Gene Therapy
Lisa Winter | Jan 7, 2020 | 2 min read
The announcement by Novartis, the maker of Zolgensma, has drawn mixed reactions from the spinal muscular atrophy community.
Those We Lost in 2019
Ashley Yeager | Dec 30, 2019 | 6 min read
The scientific community said goodbye to Sydney Brenner, Paul Greengard, Patricia Bath, and a number of other leading researchers this year.
Circulating Fetal Cells Sequenced for Prenatal Testing Study
Emily Makowski | Dec 10, 2019 | 3 min read
Trophoblasts, collected from the mother during a blood draw, can determine fetal genetic abnormalities currently diagnosed through amniocentesis or chorionic villi sampling.
Spaceflight Alters Genes of Human Stem Cell–Derived Heart Cells
Emily Makowski | Nov 7, 2019 | 3 min read
Cardiomyocytes made from iPSCs aboard the International Space Station had upregulated mitochondrial functioning.
Increased Neuronal Activity Shortens Lifespan in Animals
Ruth Williams | Oct 16, 2019 | 3 min read
Suppressing the natural age-related increase in neuronal excitation lengthens the lives of worms, and there are indications that the same may be true for mice and humans.
Cigall Kadoch Unravels Chromatin’s Role in Cancer
Chia-Yi Hou | Sep 1, 2019 | 3 min read
The Dana-Farber Cancer Institute researcher is developing cancer therapeutics based on how the physical structure of DNA contributes to the disease.
Exercise Changes Our Gut Microbes, But How Isn’t Yet Clear
Ashley Yeager | Aug 15, 2019 | 5 min read
Physical activity, independent of diet, shifts the composition of bacteria in the intestines, spurring researchers to search for species that might provide benefits akin to working out.
shinkai submersible
Elusive Asgard Archaea Finally Cultured in Lab
Nicoletta Lanese | Aug 12, 2019 | 3 min read
The 12-year-long endeavor reveals Prometheoarchaeum as a tentacled cell, living in a symbiotic relationship with methane-producing microbes.
arida1 pi3ka gene endometriosis uterine cancer uterus cell migration
Two Genes Conspire in Endometriosis and Cancer to Help Cells Migrate
Emma Yasinski | Aug 9, 2019 | 3 min read
The genes promote the migration of endothelial cells outside of the uterus, a characteristic of both endometriosis and endometrial cancers, a study of mice and human tissue finds.
Tardigrades May Have Made it to the Moon
Ashley Yeager | Aug 7, 2019 | 2 min read
An Israeli lunar lander carrying the tiny animals crashed into the moon in April, and now scientists are trying to determine if the creatures are still alive.
translation gene genetics ribosome enhancers knowable magazine
What Does It Look Like to “Turn On” a Gene?
Alla Katsnelson, Casey Rentz, and Knowable Magazine | May 3, 2019 | 8 min read
Only recently have scientists directly witnessed this most pivotal of events in biology, thanks to new technology that allows them to observe the process in living cells. It’s teaching them a lot.
gene therapy mouse mice model retinal disease retinitis pigmentosa
Image of the Day: Cone Preservation
Chia-Yi Hou | Apr 30, 2019 | 1 min read
Researchers treat mice with retinitis pigmentosa using a gene therapy that reduces cone loss.
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