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New technologies reveal the dynamic changes in mouse and human embryos during the first week after fertilization.

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image: My Mighty Mouse

My Mighty Mouse

By Megan Scudellari | April 1, 2015

Personal drug regimens based on xenograft mice harboring a single patient’s tumor still need to prove their true utility in medicine.

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image: Deploying the Body’s Army

Deploying the Body’s Army

By Jamie Green and Charlotte Ariyan | April 1, 2014

Using patients’ own immune systems to fight cancer


image: Models of Transparency

Models of Transparency

By Joan K. Heath, David Langenau, Kirsten C. Sadler, and Richard White | April 1, 2013

Researchers are taking advantage of small, transparent zebrafish embryos and larvae—and a special strain of see-through adults—to understand the development and spread of cancer.


image: Lamarck and the Missing Lnc

Lamarck and the Missing Lnc

By Kevin V. Morris | October 1, 2012

Epigenetic changes accrued over an organism’s lifetime may leave a permanent heritable mark on the genome, through the help of long noncoding RNAs.



By Robin A. Weiss and Peter Hale | June 1, 2011

Looking back, looking ahead


image: Taking Aim at Melanoma

Taking Aim at Melanoma

By Keith T. Flaherty | April 1, 2011

Understanding oncogenesis at the molecular level offers the prospect of tailoring treatments much more precisely for patients with advanced cases of this deadliest of skin cancers.


image: Epigenetic Changes in Cancer

Epigenetic Changes in Cancer

By Manel Esteller | March 1, 2011

The study of how covalent marks on DNA and histones are involved in the origin and spread of cancer cells is also leading to new therapeutic strategies.


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