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tag long fragment reads epigenetics reproducibility

Unmasking Secret Identities
Kate Yandell | Feb 1, 2014 | 9 min read
A tour of techniques for measuring DNA hydroxymethylation
How Groups of Cells Cooperate to Build Organs and Organisms
Michael Levin | Sep 1, 2020 | 10+ min read
Understanding biology’s software—the rules that enable great plasticity in how cell collectives generate reliable anatomies—is key to advancing tissue engineering and regenerative medicine.
Physical Scientists May Be Key To Speedup of Gene Sequencing
Christine Mlot | May 12, 1991 | 7 min read
Chemist Lloyd M. Smith's entry into the world of gene sequencing came about during his postdoc days, in Leroy Hood's molecular biology lab at the California Institute of Technology in Pasadena. With his background in fluorescence chemistry and instrumentation, Smith saw a way to speed the tedious process of reading DNA sequences off gels. The result was the development of the first automated DNA sequencer (L.M. Smith, et al., "Fluorescence Detection in Automated DNA Sequence Analysis," Nature,
2019 Top 10 Innovations
The Scientist | Dec 1, 2019 | 10+ min read
From a mass photometer to improved breath biopsy probes, these new products are poised for scientific success.
Can Viruses in the Genome Cause Disease?
Katarina Zimmer | Jan 1, 2019 | 10+ min read
Clinical trials that target human endogenous retroviruses to treat multiple sclerosis, ALS, and other ailments are underway, but many questions remain about how these sequences may disrupt our biology.
Top 10 Innovations 2015
The Scientist | Dec 1, 2015 | 10+ min read
The newest life-science products making waves in labs and clinics
Reveling in the Revealed
Kelly Rae Chi | Jan 1, 2016 | 7 min read
A growing toolbox for surveying the activity of entire genomes
Scaling to Singles
Kelly Rae Chi | May 1, 2016 | 9 min read
Tips for tracing transcription in individual cells
Software Solutions to Proteomics Problems
Bob Sinclair | Oct 14, 2001 | 10 min read
As genome sequencing becomes a regular occurrence, biology's attention can turn to the next logical step: proteomics. Fundamentally, proteomics is nothing less than the complete catalog of every protein in a given tissue, organ, or organism under a defined growth or disease state. Sometimes this definition is expanded to include protein-protein interactions. The data describe the types and quantities of proteins present and also indicate other proteins with which these molecules are complexed.
Expression Detection: Identify Differentially Expressed Genes with Differential Display Kits
Laura Defrancesco | Apr 26, 1998 | 10+ min read
Differential display, invented in 1992 by Liang and Pardee, ( Science, 257:967-71, 1992) has, in the few years since its description, become the premier technique for studying gene expression. Accordingly, a number of companies have jumped into the market with kits and tools for using this technology. The beauty of this method is that it enables side-by-side comparisons of complex expression patterns from as many samples as can fit on a gel, and eliminates the need for what can be at times tedi

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