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Assays by the Score
Deborah Fitzgerald | May 27, 2001 | 9 min read
Click to view the PDF file: Bead-based Fluorescent Multiplex Protein Analysis Systems Courtesy of LINCO ResearchLabMAP-based systems use internally dyed fluorescent microspheres to analyze as many as 100 different analytes concurrently. Today's competitive, high-paced research environment has stimulated the development of a host of approaches for rapid, cost-efficient analyses of large numbers of samples. In keeping with this trend, methods for simultaneously analyzing multiple species in a g
Surpassing the Law of Averages
Jeffrey M. Perkel | Sep 1, 2009 | 7 min read
By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.
Phospho-Mania
Aileen Constans | Nov 7, 2004 | 6 min read
ERK1/2 ACTIVATIONCourtesy of Biosource Internationalis plainly visible in heart tissue from an MHC-Rac1 transgenic mouse (right), compared with its normal counterpart (left). Green, pERK 1/2 (pTEpY185/187); blue, actin; red, nuclei.Protein phosphorylation is one of the most widely studied posttranslational modifications, with good reason. Many cellular signaling events rely on the addition or subtraction of phosphate groups (by kinases and phosphatases, respectively) to serine, threonine, and ty
Variations on a Gene
Amy Francis | Jul 23, 2000 | 10+ min read
Photodisc Although President Bill Clinton surely had something in mind during his 2000 State of the Union address when he asked the nation to "celebrate our diversity," insights into human diversity at the molecular level are promising to speed drug discovery and revolutionize medicine to mark- edly improve human health. Individuals differ at one in 1,000 base pairs, which adds up to a whopping number of human genetic variations when applied to the roughly three billion base pairs of the human g
Miniaturization, Parallel Processing Come To Lab Devices
Sara Latta | Sep 14, 1997 | 7 min read
The laboratory is shrinking. Scientists and engineers are borrowing miniaturization, integration, and parallel-processing techniques from the computer industry to develop laboratory devices and procedures that will fit on a wafer or microchip. A growing number of companies and investors are betting that the technology will revolutionize drug development, genomics, environmental monitoring, forensics, and clinical diagnostics, in much the same way the microprocessor transformed the computer indu

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