The largest study to date of the animals’ genetics provides robust evidence that they are adapting to survive a highly lethal, contagious cancer scientists feared would cause their extinction.
In the largest effort to date to standardize performance metrics of the cancer diagnostic across products, researchers say the products can likely detect advanced tumors reliably, but early-stage malignancies would remain a challenge.
A mutant protein called Siglec-XII may promote carcinoma progression in humans, but inactivation of its gene seems to avoid the problem, according to a study.
Clinical trials were halted after the treatment’s vector that ferries in the healthy genetic sequence was identified in the genome of a patient’s cancer cells.
A cancer researcher with a talent for leadership, Marks turned the Memorial Sloan Kettering Cancer Center into one of the world’s foremost oncology research institutions.
When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.
In the first clinical study of its kind in the US, researchers used CRISPR to modify CAR T cells to make them more potent against cancer, but the clinical benefits are unknown.
The Oxford researcher’s work on lipid and peptide antigens revealed key mechanisms in inflammation, immunotherapy, and vaccination, which are being pursued in clinical trial treatments.
Mouse fathers whose sperm lacks the gene Kdm6a pass down altered methylation patterns to male offspring, along with a better chance of developing tumors and dying.