Jeffrey M. Perkel | Apr 1, 2006 | 2 min read
Credit: COURTESY OF MARISA DOLLED-FILHAST, HISTO Rx" /> Credit: COURTESY OF MARISA DOLLED-FILHAST, HISTO Rx Traditional histopathology analysis has two basic problems. First, it isn't granular enough: Pathologists typically grade overall marker-staining intensity using a four-point scale. The other problem is that these measurements don't account for the sometimes-subtle changes in subcellular localization that can indicate disease. Beta-catenin, for instance, is a biomarker for colon can