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tag rare diseases genetics genomics microbiology culture

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Haydeh Payami is wearing a purple dress and an orange and pink scarf and standing in front of a whiteboard.
A Microbial Link to Parkinson’s Disease
Mariella Bodemeier Loayza Careaga, PhD | Dec 4, 2023 | 6 min read
Haydeh Payami helped uncover the genetic basis of Parkinson’s disease. Now, she hopes to find new ways to treat the disease by studying the gut microbiome.
A twisted and folded illustration of single-stranded RNA in front of a blue background.
Deficient RNA Editing Implicated in Inflammatory Disease 
Alejandra Manjarrez, PhD | Aug 5, 2022 | 3 min read
Genetic variants that reduce the editing levels of double-stranded RNA are associated with autoimmune and immune-mediated conditions, a study finds.
3D illustration of greenish-brown rod-shaped bacteria.
A Novel Molecule to Tackle Drug-Resistant Bugs
Aparna Nathan, PhD | Feb 12, 2024 | 4 min read
A new antibiotic is the first to block a critical transport mechanism in drug-resistant bacteria.
Layered visual representation of multiomics
Integrate and Innovate with NGS and Multiomics
The Scientist and Illumina | May 4, 2023 | 6 min read
Researchers across disciplines combine layers of discovery obtained with accessible NGS-based multiomics approaches.
Photograph from 1918 influenza pandemic shows mask-wearing women holding stretchers at backs of ambulances in Saint Louis, Missouri.
100-Year-Old Lungs Yield Genetic Samples of 1918 Flu Viruses
Christie Wilcox, PhD | May 18, 2021 | 2 min read
Influenza RNA sequences from three sets of lungs preserved in formalin since 1918 provide new insights into the deadly pandemic.
3D representation of a DNA helix and with a base offset from the main helix, illustrating the concept of base editing.
A CRISPR Alternative for Correcting Mutations That Sensitize Cells to DNA Damage
Deanna MacNeil, PhD | Oct 10, 2022 | 3 min read
Researchers turned to base editors to correct mutations causing the rare genetic disease Fanconi anemia without inducing double-strand DNA breaks.
Medical illustration of a scientist replacing part of a DNA molecule with tweezers, representing genome editing.
On the Hunt for the Next Breakthrough in Motor Neuron Disease
Deanna MacNeil, PhD | May 9, 2023 | 3 min read
Researchers leave no stone unturned in the search for a spinal muscular atrophy treatment strategy that uses base editing.
Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.

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