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image: CRISPR System Targets RNA in Mammalian Cells

CRISPR System Targets RNA in Mammalian Cells

By Anna Azvolinsky | October 4, 2017

Researchers engineer bacterial CRISPR-Cas13 to knock down RNA in mammalian cells.

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Two freely available databases include data on hundreds of human cancer cell lines. 

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image: Mammalian Immunity: What’s RNAi Got to Do with It?

Mammalian Immunity: What’s RNAi Got to Do with It?

By Shawna Williams | July 21, 2017

A new study adds to the evidence that mammalian cells can use small interfering RNAs to defend against viruses, but questions remain about physiological importance.

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image: First RNAi Insecticide Approved

First RNAi Insecticide Approved

By Aggie Mika | June 27, 2017

This month, the EPA registered four products that include RNA interference technology intended to control corn rootworms. 

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image: The RNA Age: A Primer

The RNA Age: A Primer

By Ruth Williams | May 11, 2017

Our guide to all known forms of RNA, from cis-NAT to vault RNA and everything in between.

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image: RNAi’s Future in Drug-Target Screening

RNAi’s Future in Drug-Target Screening

By Catherine Offord | April 17, 2017

A recent CRISPR study contradicted years of RNA interference research on a well-studied cancer drug target. But is it the last nail in the coffin for RNAi as a screening tool? 

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image: RNA Interference Between Kingdoms

RNA Interference Between Kingdoms

By Kerry Grens | February 1, 2017

Plants and fungi can use conserved RNA interference machinery to regulate each other’s gene expression—and scientists think they can make use of this phenomenon to create a new generation of pesticides.

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image: Oligonucleotide Therapeutics Near Approval

Oligonucleotide Therapeutics Near Approval

By Catherine Offord | December 1, 2016

Successful late-stage clinical trials could mark the maturation of a new drug development platform, but the path to commercialization is not without hurdles.

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image: Gut Bacteria Vectors

Gut Bacteria Vectors

By Ruth Williams | June 1, 2016

Researchers mix bacteria genetically engineered to express double-stranded RNA into insect food.

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image: Questions Over <em>C. elegans</em> Life Span Factors

Questions Over C. elegans Life Span Factors

By Catherine Offord | June 1, 2016

A recent paper challenges earlier findings that germline factors expressed in normal body cells influence life span in C. elegans.

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