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image: Primary Cilia in Neurons Linked to Obesity

Primary Cilia in Neurons Linked to Obesity

By Abby Olena | January 8, 2018

Three studies—one of mice and two of human genetics—describe the role of two proteins, adenylyl cyclase and melanocortin 4 receptor, in the development of obesity and diabetes. 

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The company’s recent effort to find new treatments for Alzheimer’s ended in disappointment.

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image: Maternal Response to Zika Damages Mouse Fetuses

Maternal Response to Zika Damages Mouse Fetuses

By Catherine Offord | January 5, 2018

Signaling pathways triggered by the mother’s immune system may cause complications during fetal development.

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image: Coriell Institute CEO Dies

Coriell Institute CEO Dies

By Kerry Grens | January 4, 2018

Michael Christman oversaw the organization’s well-known biobank and pioneered a personalized medicine initiative.

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image: Alcohol Damages Mouse DNA

Alcohol Damages Mouse DNA

By Jef Akst | January 3, 2018

A byproduct of alcohol consumption causes mutations in the DNA of mouse blood stem cells, and some of the breaks are not repaired.

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The genome of an infant who lived in Alaska thousands of years ago represents a previously unknown group of humans called Ancient Beringians, who share a common lineage with other Native Americans. 

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image: Child Receives Transgenic Skin

Child Receives Transgenic Skin

By Ruth Williams | January 1, 2018

A combination gene-and-cell therapy has given a boy with a grievous skin disease a new lease on life, and resolved a dermatology debate to boot.

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image: Annina Schmid Dissects Nerve Disorders

Annina Schmid Dissects Nerve Disorders

By Catherine Offord | January 1, 2018

A background in physiotherapy helps the Oxford-based researcher mix basic science with clinical work to better understand pain stemming from nerve compression.

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image: Contributors

Contributors

By Jef Akst and Katarina Zimmer | January 1, 2018

Meet some of the people featured in the January 2018 issue of The Scientist.

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image: David Julius Probes the Molecular Mechanics of Pain

David Julius Probes the Molecular Mechanics of Pain

By Anna Azvolinsky | January 1, 2018

For nearly 30 years, the UC San Francisco researcher has delved into unexplored corners of the nervous system.

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