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image: Making CAR T-Cell Therapy Safer

Making CAR T-Cell Therapy Safer

By Catherine Offord | April 1, 2017

Following a spate of patient deaths in clinical trials testing modified T cells for the treatment of cancer, researchers work to reduce the treatment’s toxicity without sacrificing efficacy.

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image: Neoantigens Enable Personalized Cancer Immunotherapy

Neoantigens Enable Personalized Cancer Immunotherapy

By Stephen P. Schoenberger and Ezra Cohen | April 1, 2017

Tumors’ mutations can encode the seeds of their own destruction, in the form of immunogenic peptides recognized by T cells.

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image: Starvation Response Triggers Melanoma Invasion

Starvation Response Triggers Melanoma Invasion

By Catherine Offord | April 1, 2017

Through similar mechanisms, amino acid depletion in culture and cytokine activity in the tumor microenvironment prompt cancer cells to metastasize.

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image: Circadian Rhythms Influence Treatment Effects

Circadian Rhythms Influence Treatment Effects

By Jyoti Madhusoodanan | April 1, 2017

Across many diseases, taking medication at specific times of day may make the therapy more effective.

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image: Infographic: Antibody Cancer Therapy

Infographic: Antibody Cancer Therapy

By Ruth Williams | April 1, 2017

An experimental technique removes T cells that aid in vitro tumor growth.

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image: Infographic: Circadian Clock Affects Health and Disease

Infographic: Circadian Clock Affects Health and Disease

By Jyoti Madhusoodanan | April 1, 2017

The body's rhythms could affect numerous ailments as well as how people respond to treatments.

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image: Infographic: Mechanisms of Resistance

Infographic: Mechanisms of Resistance

By Anna Azvolinsky | April 1, 2017

Cancers appear to be able to evolve resistance to many of the therapies doctors have tried.

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image: Infographic: Targeting Cancer Antigens

Infographic: Targeting Cancer Antigens

By Stephen P. Schoenberger and Ezra Cohen | April 1, 2017

Neoantigens may serve as valuable targets for new immunotherapies.

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image: Targeting Tregs Halts Cancer’s Immune Helpers

Targeting Tregs Halts Cancer’s Immune Helpers

By Ruth Williams | April 1, 2017

New monoclonal antibodies kill both cancer-promoting immunosuppressive cells and tumor cells in culture.

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image: Anti-Flavivirus Antibodies Enhance Zika Infection in Mice

Anti-Flavivirus Antibodies Enhance Zika Infection in Mice

By Anna Azvolinsky | March 30, 2017

Researchers report evidence of antibody-dependent enhancement in a Zika-infected, immunocompromised mouse model.

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