The nationwide experiment will initially include around 100,000 volunteers.
The acute pain that results from injury or disease is very different from chronic pain.
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Cone snail venom researcher Mandë Holford discusses the therapeutic potential of toxins found in animals.
The race to develop analgesic drugs that inhibit sodium channel NaV1.7 is revealing a complex sensory role for the protein.
A cornucopia of toxins in the animal kingdom could provide inspiration for novel painkillers, but so far, effective drugs have proven elusive.
Decades after their discovery by bioprospectors, amphibian-derived analgesics continue to attract scientific attention.
Arachnids harbor a plentiful array of molecules that target mammalian pain receptors.
Studying cone snail venom has yielded novel pain pathways, but the peptides that function as toxins are difficult to translate into drugs.
Venomous centipedes may harbor a clue to the creation of a successful pain-killing compound for humans.
If successful, the treatments could alleviate patients’ pain by reducing inflammation.
Compounds in the arachnids’ venom interact with ion channels to both cause and block pain.
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