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tag knockout mice neuroscience

How Well Do Mice Model Humans?
Ricki Lewis | Oct 25, 1998 | 8 min read
STRIKING RESEMBLANCE: James Croom, who studies Down syndrome mice at North Carolina State University, says the animals are providing valuable information useful to humans. When a page-one article in the May 3, 1998, Sunday New York Times portrayed angiogenesis inhibitors that fight cancer in mice as being possible just around the corner for humans, criticism for raising false hopes erupted. Merely 10 weeks later, however, when researchers from the University of Hawaii reported cloning the fi
T Cells and Neurons Talk to Each Other
Ashley Yeager | Oct 1, 2020 | 10+ min read
Conversations between the immune and central nervous systems are proving to be essential for the healthy social behavior, learning, and memory.
Into the Limelight
Kate Yandell | Oct 1, 2015 | 8 min read
Glial cells were once considered neurons’ supporting actors, but new methods and model organisms are revealing their true importance in brain function.
Scientists Strike a Cord
Rabiya Tuma | Feb 9, 2003 | 6 min read
Courtesy of SR Eng  BABY STAINS: The head of a transgenic murine embryo in which a marker enzyme has been specifically expressed in the sensory neurons of the trigeminal and dorsal root ganglia. The marker allows staining of the projections of these neurons into, among other areas, the hindbrain and spinal cord. (S.R. Eng et al., "Defects in sensory axon growth precede neuronal death in Brn3a-deficient mice," J Neurosci, 21:541-9, 2001.) Somewhere in the 200 million bases of the human ge
New Molecular Tools Revealing Mysteries Of The Mind
Karen Young Kreeger | Feb 2, 1997 | 10 min read
Sidebar: Society for Neuroscience NEW MESSENGERS: Caltech’s Erin Schuman and colleagues discovered that one form of nitric oxide is important to long-term potentiation. Can you recall where you were when you heard about the explosion of the space shuttle Challenger? Why is it that, almost universally, people can remember with vivid and instantaneous detail this tragic event when they can't recall what they had for dinner just days before? How are some memories indelibly hard-wired into o
Porcine Possibilities
Ricki Lewis | Oct 15, 2000 | 8 min read
Courtesy of PPL TherapeuticsA new generation of pigs. Headlines in late summer 2000 introduced long-awaited reports on pig cloning and retroviral transmission to mice, pig cells healing rat spinal cords, and a gaff by Dolly dad Ian Wilmut erroneously heralding halt of xenograft work at the Roslin Institute near Edinburgh, Scotland. So it seemed that the question of whether pigs can pass their retroviruses to humans might finally be on the road to resolution. Not quite. Pigs, as the purveyors o
Cannabinoid controversy
Tia Ghose | Sep 9, 2009 | 5 min read
Receptors that bind the active ingredient in marijuana may be novel therapeutic targets in autoimmune disease, but contested evidence for their presence on neurons could hamper drug development
MicroRNA may modulate memory
Melissa Lee Phillips | Jan 18, 2006 | 3 min read
Researchers report that the non-coding RNAs influence protein synthesis at synapses
A Master Regulator in the Brain
Per Svenningsson and Paul Greengard | Oct 1, 2006 | 10+ min read
How a single protein was found to link schizophrenia and depression to drugs of abuse and addiction. 
Illuminating Behaviors
Douglas Steinberg | Jun 1, 2003 | 6 min read
Courtesy of Genevieve Anderson If not for Nobel laureates Thomas Hunt Morgan, Eric R. Kandel, and Sydney Brenner, the notion of a general behavioral model might seem odd. Behaviors, after all, are determined by an animal's evolutionary history and ecological niche. They are often idiosyncratic, shared in detail only by closely related species. But, thanks to Morgan's research in the early 20th century, and Kandel's and Brenner's work over the past 35 years, the fly Drosophila melanogaster, t

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