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tag horizontal gene transfer neuroscience culture disease medicine

Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Brain cell in purple on a black background. Arc mRNAs are labeled green and are mainly localized in the cell nucleus and in the dendrites.
Short-lived Molecules Support Long-term Memory 
Alejandra Manjarrez, PhD | Jun 6, 2023 | 3 min read
A gene essential for information storage in the brain engages an autoregulatory feedback loop to consolidate memory.
Week in Review: March 9–13
Tracy Vence | Mar 13, 2015 | 4 min read
Modifying mouse memories; mitochondria-disrupting antibiotics; horizontal gene transfer across animals; T cells target dengue; optogenetics without the genetics
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Neuroscience
The Scientist Staff | Jul 24, 1994 | 2 min read
P. Ernfors, J.-P. Merlio, H. Persson, "Cells expressing mRNA for neurotrophins and their receptors during embryonic rat development," European Journal of Neuroscience, 4:1140-58, 1992. Patrik Ernfors (Whitehead Institute for Biomedical Research, Cambridge, Mass.): "Previous studies by other researchers have shown that neurotrophins can prevent the cell death of partially overlapping, but also specific, sets of neurons in culture.
Neuroscience
The Scientist Staff | Jul 24, 1994 | 2 min read
P. Ernfors, J.-P. Merlio, H. Persson, "Cells expressing mRNA for neurotrophins and their receptors during embryonic rat development," European Journal of Neuroscience, 4:1140-58, 1992. Patrik Ernfors (Whitehead Institute for Biomedical Research, Cambridge, Mass.): "Previous studies by other researchers have shown that neurotrophins can prevent the cell death of partially overlapping, but also specific, sets of neurons in culture.
A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.
Defying Dogma: Decentralized Translation in Neurons
Danielle Gerhard, PhD | Sep 8, 2023 | 10+ min read
To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.
Reprogrammed Müller Glia Restore Vision in Mice
Ashley Yeager | Aug 15, 2018 | 4 min read
A double gene-transfer therapy transformed the non-neuronal cells into rod photoreceptors in the retinas of animal models of congenital blindness.
Conceptual image showing molecules making up a brain shape
The Noncoding Regulators of the Brain
Christie Wilcox, PhD | Sep 12, 2022 | 10+ min read
Noncoding RNAs are proving to be critical players in the evolution of brain anatomy and cognitive complexity.

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