Jeffrey Perkel | Mar 3, 2002 | 4 min read
J.S. Andersen et al., "Directed proteomic analysis of the human nucleolus," Current Biology, 12:1-11, Jan. 8, 2002. F1000 Recommendation: Must Read "This is a good paper showing the large scale analysis of a very large protein complex, the nucleolus. [Points of interest]: The size of the complex and that it is dynamic. The mass spectrometry methods used here were a combination of high throughput (matrix-assisted laser desorption ionization coupled to time of flight detection) and low throughpu