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tag cis regulatory elements immunology

Top 7 in Immunology
Edyta Zielinska | Aug 2, 2011 | 3 min read
A snapshot of the most highly ranked articles in microbiology and related areas, from Faculty of 1000
Jorge Henao-Mejia Explores the Immune System’s Controls
Sukanya Charuchandra | Jan 1, 2019 | 3 min read
By tying together his understanding of the microbiome and nucleic acids, the UPenn immunologist is decoding the underlying causes of inflammation and disease.
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.
Master Plans
Karen Hopkin | Aug 1, 2009 | 7 min read
By Karen Hopkin Master Plans Sean Carroll earned his celebrity by stitching together the patterning that underlies much of the animal kingdom’s various shades and shapes. © Eric Tadsen Sean Carroll’s most flamboyant finding was prompted by an innocent query before a seminar. Carroll had gone down to Duke University to give a talk about his research on the genes and molecules that direct the regular spacing of bri
Notable
Jeffrey Perkel | Mar 3, 2002 | 4 min read
J.S. Andersen et al., "Directed proteomic analysis of the human nucleolus," Current Biology, 12:1-11, Jan. 8, 2002. F1000 Recommendation: Must Read "This is a good paper showing the large scale analysis of a very large protein complex, the nucleolus. [Points of interest]: The size of the complex and that it is dynamic. The mass spectrometry methods used here were a combination of high throughput (matrix-assisted laser desorption ionization coupled to time of flight detection) and low throughpu
Unmasking Secret Identities
Kate Yandell | Feb 1, 2014 | 9 min read
A tour of techniques for measuring DNA hydroxymethylation
Creative Expression: Mammalian Expression Vectors and Systems
Christopher Smith | Feb 1, 1998 | 7 min read
Date: February 2, 1998 Chart 1 Chart 2 Prokaryotic expression systems, reviewed in the September 1, 1997, issue of The Scientist were part of the early repertoire of research tools in molecular biology. Although the expression of recombinant protein in prokaryotes provided a means to develop other research tools (antibodies, for example ) and study basic aspects of biological function, the scope and depth of this research were limited, especially with regard to eukaryotic proteins. The de novo
Finding a Mate
Barbara Cunningham | Apr 1, 2001 | 9 min read
Available Two-hybrid Systems Graphic: Leza BerardoneGenome sequencing has produced a vast supply of proteins in need of a functional identity. One way to identify a protein's function is to identify its interacting partners, because proteins often work in pairs or as part of large complexes. Scientists traditionally have used biophysical or biochemical methods (such as affinity chromatography or co-immunoprecipitation) to study protein-protein interactions. More recently, two-hybrid and phage-d
Choosing the Best Reporter Assay
Hillary Sussman | Jul 22, 2001 | 10+ min read
Suppliers of Reporter Assay Screening Systems Courtesy of Applied BiosystemsTarget practice: Researchers can employ reporter assays to study a variety of cellular processes. Rarely is the product of a gene readily distinguishable from the myriad mRNA and protein complements that exist in a cell at any point in time. But researchers can skirt this obstacle by placing a "reporter gene" under the same controls as the gene of interest. Reporter genes have easily measurable phenotypes that form th

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