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tag hiv infectivity cell molecular biology

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
Green and red fluorescent proteins in a zebrafish outline the animal’s vasculature in red and lymphatic system in green in a fluorescent image. Where the two overlap along the bottom of the animal is yellow.
Serendipity, Happenstance, and Luck: The Making of a Molecular Tool
Shelby Bradford, PhD | Dec 4, 2023 | 10+ min read
The common fluorescent marker GFP traveled a long road to take its popular place in molecular biology today.
Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Black and gold sketch of Katalin Karikó and Drew Weissman.
Nobel Prize for mRNA Vaccines
Danielle Gerhard, PhD | Oct 2, 2023 | 5 min read
Katalin Karikó and Drew Weissman received this year’s Physiology or Medicine award for their work on RNA biology and mRNA-based vaccines.
Researchers Dissect the Mechanisms of HIV Infection
Jeffrey Perkel | May 26, 2002 | 6 min read
Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. For all that is known about human immunodeficiency virus (HIV), some remarkably fundamental questions remain. One of the most notable, perhaps, is just how HIV manages to infect its primary target, CD4+-T cells, when so few of those cells can be found at the virus' typical entry points: the v
Systems Immunology: Understanding Responses to Vaccination and Infection
The Scientist | Mar 18, 2019 | 1 min read
The Scientist is bringing together a panel of experts to discuss their research and experiences in using systems immunology to gain new insights into immune responses to infection through single-cell data analysis, and into innate immune dysfunction in HIV infection.  
Sex Differences in Immune Responses to Viral Infection
Catherine Offord | Mar 1, 2021 | 10+ min read
Stronger interferon production, greater T cell activation, and increased susceptibility to autoimmunity are just some of the ways that females seem to differ from males.
The Vaginal Microbiome is Finally Getting Recognized
Hannah Thomasy, PhD, Drug Discovery News | Sep 25, 2023 | 10+ min read
Vaginal dysbiosis has long been a taboo subject, but studying and optimizing the vaginal microbiome could be a game changer for women's health.
Measuring Latent HIV
Abby Olena, PhD | Oct 24, 2013 | 3 min read
The latent HIV provirus reservoir persisting in CD4+ T cells is potentially 60 times larger than previously believed, researchers show.

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