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Studies of infected rhesus monkeys reveal the virus’s long-term hiding places in the body.

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image: Viral Trigger for Celiac Disease?

Viral Trigger for Celiac Disease?

By Anna Azvolinsky | April 6, 2017

A common, seemingly benign human virus can trigger an immune response that leads to celiac disease in a mouse model, researchers show. 

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image: Contributors

Contributors

By Diana Kwon | April 1, 2017

Meet some of the people featured in the April 2017 issue of The Scientist.

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image: Gel Scaffolds for Delivery of Immunotherapies

Gel Scaffolds for Delivery of Immunotherapies

By Rachel Berkowitz | April 1, 2017

Using biocompatible polymers to carry cancer immune therapies directly to the tumor

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image: Hitting It Out of the Park

Hitting It Out of the Park

By Mary Beth Aberlin | April 1, 2017

Cancer can be as evasive and slippery as a spitball, but new immunotherapies are starting to connect.

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image: Location, Location, Location

Location, Location, Location

By Anna Azvolinsky | April 1, 2017

Since first proposing that a cell’s function and biology depend on its surroundings, Mina Bissell continues to probe the role of the extracellular matrix.

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image: Making CAR T-Cell Therapy Safer

Making CAR T-Cell Therapy Safer

By Catherine Offord | April 1, 2017

Following a spate of patient deaths in clinical trials testing modified T cells for the treatment of cancer, researchers work to reduce the treatment’s toxicity without sacrificing efficacy.

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Measuring PD-L1 levels was a great start. Now we need to quantify more protein biomarkers, assess the tumor mutational landscape, and examine immune cell signatures, too.

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image: Neoantigens Enable Personalized Cancer Immunotherapy

Neoantigens Enable Personalized Cancer Immunotherapy

By Stephen P. Schoenberger and Ezra Cohen | April 1, 2017

Tumors’ mutations can encode the seeds of their own destruction, in the form of immunogenic peptides recognized by T cells.

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image: Circadian Rhythms Influence Treatment Effects

Circadian Rhythms Influence Treatment Effects

By Jyoti Madhusoodanan | April 1, 2017

Across many diseases, taking medication at specific times of day may make the therapy more effective.

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