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tag toxicity neuroscience

Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Scanning electron micrograph (SEM) of the unicellular yeast Saccharomyces cerevisiae, known as Baker's or Brewer's yeast.
Yeast Models Provide New Insights into Neurodegenerative Diseases
Mahlon Collins | Oct 1, 2021 | 10+ min read
The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.
Using Temperature-Sensitive Channels to Study Neural Circuitry
Devika G. Bansal | Nov 1, 2018 | 8 min read
Meet the researchers building a thermogenetic toolbox.
Arsenic and Old Protein Labels
Brendan Maher | May 26, 2002 | 2 min read
For a team at the University of California, San Diego, nine years of tinkering with arsenic paid off in the development of a new technique that can tag proteins with different colors over time and even zero in to electron microscopic resolution. Roger Tsien, Howard Hughes Medical Institute investigator and professor of pharmacology, chemistry, and biochemistry at UCSD, says the project started with the suggestion from a colleague that one can tag a two-cysteine sequence in a protein with a singl
The Genes of Parkinsonā€™s Disease
Bobby Thomas and M. Flint Beal | Feb 1, 2011 | 10 min read
The minority of Parkinson’s cases now known to have genetic origins are shedding light on the cellular mechanisms of all the rest, bringing researchers closer to a cause—and perhaps a cure.
Is Cannabis Really That Bad?
Sabrina Richards | Jan 23, 2013 | 4 min read
Though some studies point to negative consequences of pot use in adolescents, data on marijuana’s dangers are mixed.
Top 10 Innovations 2013
The Scientist | Dec 1, 2013 | 10+ min read
The Scientist’s annual competition uncovered a bonanza of interesting technologies that made their way onto the market and into labs this year.
Imaging Chromatin to Deduce Function from Form
Marissa Fessenden | Dec 1, 2018 | 7 min read
Researchers describe their tools for probing how the physical shape of the genome affects genes’ function.
Antibody Alternatives
Paul Ko Ferrigno and Jane McLeod | Feb 1, 2016 | 10+ min read
Nucleic acid aptamers and protein scaffolds could change the way researchers study biological processes and treat disease.

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