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tag techniques microbiology evolution ecology immunology

Mining Bacterial Small Molecules
L. Caetano M. Antunes, Julian E. Davies and B. Brett Finlay | Jan 1, 2011 | 10 min read
As much as rainforests or deep-sea vents, the human gut holds rich stores of microbial chemicals that should be mined for their pharmacological potential.
Wrestling with Recurrent Infections
Gayatri Vedantam and Glenn S. Tillotson | May 1, 2011 | 10+ min read
Clostridium difficile is evolving more robust toxicity, repeatedly attacking its victims, and driving the search for alternative therapies to fight the infection.
Targeting Antibiotic-Resistant Bacteria with CRISPR and Phages
Anna Azvolinsky | May 18, 2015 | 3 min read
Researchers develop a CRISPR-based, two-phage system that sensitizes resistant bacteria to antibiotics and selectively kills any remaining drug-resistant bugs. 
Get the Basics
Gail Dutton | Nov 10, 2002 | 6 min read
Photo: Courtesy of Michelle Lizott Waniewski  DROP AND GIVE ME 20! Attendees at the 2002 NEB workshops labor through basic training. If you've ever been confused by the jargon of molecular biology, you are not alone. With biotechnology in the news day by day, it is easy to forget that for many of us--even for some readers of The Scientist--the tools, techniques, and concepts that undergird much of this research are foreign. To help keep up, some scientists are queuing up to learn the bas
60 Members Elected to NAS
Barry Palevitz | Jun 25, 2000 | 6 min read
Editor's Note: On May 2, the National Academy of Sciences announced the election of 60 new members and 15 foreign associates from nine countries in recognition of their distinguished and continuing achievements in original research. Nearly half of the new members are life scientists. In this article, The Scientist presents photographs of some of the new members and comments from a few of them on their careers and on past and current research. A full directory of NAS members can be found online a
Wrestling with Recurrent Infections
Gayatri Vedantam and Glenn S. Tillotson | May 1, 2011 | 9 min read
By Gayatri Vedantam and Glenn S. Tillotson Wrestling with Recurrent Infections Clostridium difficile is evolving more robust toxicity, repeatedly attacking its victims, and driving the search for alternative therapies to fight the infection. photoillustration by Sean Mccabe; Science Photo Library (boy); Sebastian Kaulitzki/ Istockphoto.com (Intestines); Olena Timashova/Istockphoto.com (Green bacteria); Jiri Flogel/Istockphoto.com (Blue bacteria) As infectiou
Chip Critics Countered
Eugene Russo | Aug 24, 2003 | 7 min read
Courtesy of Gary Churchill  THE GOOD, THE BAD, AND THE FILTERED: At left is a poor quality microarray with problems due to background contamination. At right is a good quality microarray with well defined spots and low background intensity. Data preprocessing methods can normalize and filter data derived from such images, which may make it impossible to detect problems apparent in the raw image data. Since their rise to fame in the mid 1990s, microarrays have been both lauded and critici
Articles Alert
Simon Silver | Jul 8, 1990 | 7 min read
The Scientist has asked a group of experts to comment periodically upon recent articles that they have found noteworthy. Their selections, presented herein every issue, are neither endorsements of content nor the result of systematic searching. Rather, the list represents personal choices of articles the columnists believe the scientific community as a whole may also find interesting. Reprints of any articles cited here may be ordered through The Genuine Article, 3501 Market St., Philadelphia,
Articles Alert
The Scientist Staff | Aug 7, 1988 | 8 min read
The Scientist has asked a group of experts to periodically comment upon recent articles that they have found noteworthy. Their selections, presented here in every issue, we neither endorsements of content nor the result of systematic searching. Rather, they are personal choices of articles they believe the scientific community as a whole may also find interesting. Reprints of any articles cited here may be ordered through The Genuine Article 3501 Market St., Philadelphia, Pa. 19104, or by telep
Biochemical, Reagents Kits Offer Scientists Good Return On Investment
Holly Ahern | Jul 23, 1995 | 8 min read
Investment Author:Holly Ahern If you were to ask several life scientists to name a particular biochemical product that they simply could not do without, you'd probably get a myriad of answers that would mirror the research interests of the group you questioned. A molecular evolutionist trying to differentiate two closely related species of monkeys by restriction fragment-length polymorphism (RFLP) analysis might cite restriction enzymes, which can cut DNA into pieces of varying length. A cell b

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