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image: Death or Damage of Dopamine Neurons

Death or Damage of Dopamine Neurons

By Bobby Thomas and M. Flint Beal | February 1, 2011

The hallmark pathology of Parkinson’s disease is the damage and death of dopamine producing neurons in the brain. 

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image: The Genes of Parkinson’s Disease

The Genes of Parkinson’s Disease

By Bobby Thomas and M. Flint Beal | February 1, 2011

The minority of Parkinson’s cases now known to have genetic origins are shedding light on the cellular mechanisms of all the rest, bringing researchers closer to a cause—and perhaps a cure.

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image: Down but Not Out

Down but Not Out

By Richard P. Grant | February 1, 2011

Cells on standby are surprisingly busy.

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image: Puzzle Me This

Puzzle Me This

By Graeme Stemp-Morlock | February 1, 2011

What substance is supposed to have no effect but can make people feel better, has no chance for a big monetary payoff but is worth billions, and is used in virtually every rigorous clinical trial but has no single, universal formulation? 

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image: Synthetic Spirits

Synthetic Spirits

By David Nutt | January 1, 2011

Can we use science to reduce the harms of alcohol?

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image: Mining Bacterial Small Molecules

Mining Bacterial Small Molecules

By L. Caetano M. Antunes, Julian E. Davies and B. Brett Finlay | January 1, 2011

As much as rainforests or deep-sea vents, the human gut holds rich stores of microbial chemicals that should be mined for their pharmacological potential.

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image: Interfering with Cancer

Interfering with Cancer

By Katherine Hyde and Paul Liu | January 1, 2011

MicroRNAs may drive the development of leukemia.

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image: Intestinal Molecular Signaling

Intestinal Molecular Signaling

By L. Caetano M. Antunes, Julian E. Davies and B. Brett Finlay | January 1, 2011

Microbes, both good and bad, can exert direct effects on host cells and vice versa. 

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image: Brave New Drugs

Brave New Drugs

By Sarah Greene | January 1, 2011

Intoxicating ideas for saving a billion lives

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image: The Coming Health Crisis

The Coming Health Crisis

By Samuel S. Myers and Aaron Bernstein | January 1, 2011

Indirect effects of global climate change threaten the health of hundreds of millions of people. The very uncertainty that shrouds this issue must serve as an organizing principle for adaptation to its ill effects.

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