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tag tips genetics genomics

A C-fern (Ceratopteris richardii) growing in a pot
Genome Spotlight: C-fern (Ceratopteris richardii)
Christie Wilcox, PhD | Sep 22, 2022 | 5 min read
Sequences for the model organism and two of its kin reveal how these plants got their oversized genomes.
Tailor-Made Genome
Tia Ghose | Jul 18, 2011 | 2 min read
A method for rapidly replacing stop codons throughout the genetic code of E. coli paves the way for biomanufacturing designer proteins.
The Human Genome
Arielle Emmett | Jul 23, 2000 | 10+ min read
Life sciences took center stage virtually around the world June 26. President Bill Clinton, flanked on the left by Celera Genomics Group president J. Craig Venter and on the right by National Human Genome Research Institute director Francis S. Collins, announced the completion of "the first survey of the entire human genome."
Sequencing Stakes: Celera Genomics Carves Its Niche
Ricki Lewis | Jul 18, 1999 | 8 min read
J. Craig Venter is no stranger to contradiction and controversy. He seems to thrive on it. In 1991, when the National Institutes of Health was haggling over patenting expressed sequence tags (ESTs)--a shortcut to identifying protein-encoding genes--Venter the inventor accepted a private offer to found The Institute for Genomic Research (TIGR) in Rockville, Md. TIGR would discover ESTs and give most of them to a commercial sibling, Human Genome Sciences (HGS), to market. ESTs are now a standard
Get With the Program
Jeffrey M. Perkel | Aug 1, 2015 | 8 min read
DIY tips for adding coding to your analysis arsenal
Whole-Genome SNP Genotyping
Marilee Ogren | Jun 1, 2003 | 8 min read
Clockwise from top left: images courtesy of Affymetrix, Illumina, Sequenom and Illumina Take any two individuals, sequence and compare their genomic DNA, and you'll find that the vast majority (about 99.9%) of the sequences are identical. In the remaining 0.1% lie differences in disease susceptibility, environmental response, and drug metabolism. Researchers are understandably keen to dissect these variations, most of which take the form of single-nucleotide polymorphisms (SNPs). A SNP (pron
A Practical Guide to the HapMap
Aileen Constans | Feb 1, 2006 | 5 min read
Here are five tips to getting the most out of your next gene-association study
Mapping Traits to Genes with CRISPR
Catherine Offord | May 5, 2016 | 4 min read
Researchers develop a technique to direct chromosome recombination with CRISPR/Cas9, allowing high-resolution genetic mapping of phenotypic traits in yeast.
Canvassing Protein Complexes
David Secko | Sep 1, 2008 | 4 min read
Two yeast studies begin to identify protein interactions on a genome-wide scale.
Mapping Subtelomeres
Ricki Lewis | Oct 14, 2001 | 4 min read
In genetics, certain terms sometimes mask what scientists do not yet understand, such as "junk DNA." Similarly, the chromosomal regions just proximal to the tips--the subtelomeres--have been dubbed "buffers," ill-defined DNA sequences that somehow support the telomeres, which control the cell cycle and cellular aging. A team of researchers from the Wistar Institute in Philadelphia, the University of California, Irvine, and John Radcliffe Hospital in Oxford, UK, has used single-copy sequences in

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