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tag neurofibrillary tangles genetics genomics

The Human Genome
Arielle Emmett | Jul 23, 2000 | 10+ min read
Life sciences took center stage virtually around the world June 26. President Bill Clinton, flanked on the left by Celera Genomics Group president J. Craig Venter and on the right by National Human Genome Research Institute director Francis S. Collins, announced the completion of "the first survey of the entire human genome."
bacteria inside a biofilm
How Bacterial Communities Divvy up Duties
Holly Barker, PhD | Jun 1, 2023 | 10+ min read
Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics.
These Organelles Have No Membranes
Michael Crabtree and Tim Nott | Dec 1, 2018 | 10+ min read
From making ribosomes to protecting the integrity of the genome, these membraneless compartments play important roles in the cell. Their behavior is rooted in basic physics.
Scanning electron micrograph (SEM) of the unicellular yeast Saccharomyces cerevisiae, known as Baker's or Brewer's yeast.
Yeast Models Provide New Insights into Neurodegenerative Diseases
Mahlon Collins | Oct 1, 2021 | 10+ min read
The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.
Bloody Isle
Newamul Khan | Apr 1, 2007 | 3 min read
Bloody Isle When genetics and history compete, who wins?By Newamul Khan ARTICLE EXTRASSPRING BOOKSStem Cells on ShelvesAn Awkward SymbiosisThe Death of Faith?High in the TreesThe Enchantment of EnhancementBooks about BodiesNew Lab ManualsIn Brief Saxons, Vikings, and Celts: The Genetic Roots of Britain and Ireland, By Bryan Sykes, 320
Diseases by Design
Jennifer Fisher Wilson | Jun 1, 2003 | 6 min read
Jacob Halaska, ©Index Stock Imagery Researchers like mice. US government statistics reveal that the whiskered ones show up in 90% of all experiments. Mice come cheap, procreate often, and die fairly quickly. And although evolution separates mouse from human by an estimated 75 to 100 million years, biologically and genetically speaking, they share a lot; as much as 85% of the DNA in mice is the same in humans. The research ground that mice have domineered for a century, however, is reced
Notebook
The Scientist Staff | Jul 6, 1997 | 7 min read
MORE WORK NEEDED: Scientists have discovered a Parkinson's disease gene, but aren’t certain how many cases are caused by its mutation. The end of June brought with it a pair of studies with potentially valuable information on neurological disorders. In one (M. Polymeropoulos et al., Science, 276:2045-7, 1997), researchers from the National Human Genome Research Institute (NHGRI) and from Robert Wood Johnson Medical School in Piscataway, N.J., reported the first-ever discovery of a gene w
Chromosome Analysis Goes High Tech
Ricki Lewis | Oct 15, 1989 | 5 min read
Since the 1 920s, when researchers began to study chromosomes, the analysis of human chromosomes has presented a particularly tough technological challenge, simply because there are so many of them. When displayed under a light microscope. the strands of human genetic material tend to bunch together maddeningly, overlapping and intertwining like so much spaghetti. For these reasons, it wasn’t until 1956 that the correct number of 46 human chromosomes (23 pairs) was clearly demonstrated.
Written in Blood
Jyoti Madhusoodanan | Apr 1, 2016 | 8 min read
A tour of evolving strategies for identifying circulating disease biomarkers
Beyond Serendipity
Paul Thomas | Nov 24, 2002 | 6 min read
We are entering the era of systems biology, where to truly understand a disease we must understand its causes from the molecular level to the organism level. The sheer number of biological molecules, and the complex nature of their interactions, has engendered a new method of biological experimentation, termed by Leroy Hood as "discovery science." Discovery science is technology-driven, and contrasted with hypothesis-driven science because it relies on making large-scale observations that are

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