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tag x ray crystallography culture

Accelerating X-ray Crystallography
Kelli Miller | Jan 12, 2003 | 8 min read
Courtesy of Astex Technology For years, the process of X-ray crystallography has moved at a tortoise's pace. "When I started in the field, it would typically take 20 person-years to produce a complete atomic model of one single protein. It was like a traffic jam in New York City. Every single part of the process was slow," says Stephen Burley, chief scientific officer and senior vice president of research at San Diego-based Structural GenomiX. The biggest holdup: obtaining a suitable crystal.
X-ray Vision in Structural Genomics
Gregory Smutzer | Jun 10, 2001 | 10 min read
Updated! Suppliers of Tools for X-ray Crystallography Courtesy of Amersham Pharmacia BiotechDetail of the electron density map of deacetoxycephalosporin C synthase from Streptomyces clavuligerus. Two important approaches can be used to determine the three-dimensional structure of macromolecules. Nuclear magnetic resonance (NMR) spectroscopy yields information on the structure of proteins in solution, but it has a size limitation of approximately 150 amino acid residues (about 16,500 daltons),
Microscopic image of a live amoeba.
Illuminating Specimens Through Live Cell Imaging
Charlene Lancaster, PhD | Mar 14, 2024 | 8 min read
Live cell imaging is a powerful microscopy technique employed by scientists to monitor molecular processes and cellular behavior in real time.
Crystal structure made easy
The Scientist Staff | May 1, 2007 | 1 min read
Credit: Courtesy of the International Union of Crystallography" /> Credit: Courtesy of the International Union of Crystallography Crystallizing proteins is a daunting task. Last year Alexander McPherson of the University of California, Irvine, and colleagues proposed a novel strategy to develop crystals quickly by including high concentrations of small molecules to the so-called mother liquors. They analyzed data on the crystallization of 81 different protein cultur
Where Proteins Meet
Aparna Sreenivasan | Aug 24, 2003 | 3 min read
Courtesy of Pierce Biotechnology Pierce Biotechnology has expanded its repertoire of protein chemistry products with the new ProFound Protein Interaction Mapping Kit, which helps researchers to pinpoint where protein partners come together. The technique takes advantage of a unique cleaving agent and bypasses the need for more complex approaches such as nuclear magnetic resonance or X-ray crystallography, says Patti Domen, a senior research scientist who designed and tested the product at Pie
Molecular Modeling Software Manufacturers Improve Functionality
Holly Ahern | Mar 19, 1995 | 8 min read
Imagine this scenario. You sit at your computer to study the structure of a crucial protein--one that you've painstakingly cloned, produced in a protein-expression system, and purified after many hours in the laboratory. The crystallography laboratory that you collaborate with produced crystals of your protein weeks ago. They collected X-ray diffraction data and plugged it into their workstation-based molecular-modeling system, coming up with a three-dimensional structure of your protein showin
Racing for the Ribosome
Venki Ramakrishnan | Dec 1, 2018 | 3 min read
Nobel laureate Venki Ramakrishnan’s new book recounts the tale of researchers striving to understand an ancient molecular machine that is essential for all life.
vaccines for viruses
Belief in the Unseen
Bob Grant | Jun 1, 2019 | 3 min read
Science doesn’t require faith, but fostering trust in its practitioners can help the public move past unfounded doubts.
Contributors
The Scientist Staff | Dec 1, 2018 | 3 min read
Meet some of the people featured in the December 2018 issue of The Scientist.
Conceptual image of coronavirus, SARS?Cov?2 infects a human cell
Viruses Target Super-Short Protein Motifs to Disrupt Host Biology
Conchita Fraguas Bringas and Jakob Nilsson | May 16, 2022 | 10+ min read
Only recently appreciated as critical components of cellular functions, unstructured stretches of amino acids called SLiMs are key to viral-host interactions.

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