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tag x ray crystallography genetics genomics developmental biology

Accelerating X-ray Crystallography
Kelli Miller | Jan 12, 2003 | 8 min read
Courtesy of Astex Technology For years, the process of X-ray crystallography has moved at a tortoise's pace. "When I started in the field, it would typically take 20 person-years to produce a complete atomic model of one single protein. It was like a traffic jam in New York City. Every single part of the process was slow," says Stephen Burley, chief scientific officer and senior vice president of research at San Diego-based Structural GenomiX. The biggest holdup: obtaining a suitable crystal.
X-ray Vision in Structural Genomics
Gregory Smutzer | Jun 10, 2001 | 10 min read
Updated! Suppliers of Tools for X-ray Crystallography Courtesy of Amersham Pharmacia BiotechDetail of the electron density map of deacetoxycephalosporin C synthase from Streptomyces clavuligerus. Two important approaches can be used to determine the three-dimensional structure of macromolecules. Nuclear magnetic resonance (NMR) spectroscopy yields information on the structure of proteins in solution, but it has a size limitation of approximately 150 amino acid residues (about 16,500 daltons),
Proteomics Factories
Eugene Russo | Feb 6, 2000 | 9 min read
Figure: Gaetano Montelione and Yuanpeng Huang of Rutgers UniversityX-ray crystal structure of human basic fibroblast growth factor. With a bit of luck and sometimes decades of dedication, scientists have in recent years revealed fascinating vistas of biological structures at the atomic level using X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy. In 1997, Timothy Richmond, a professor of X-ray crystallography at the Swiss Federal Institute of Technology in Zurich, complete
Building On Firm Foundations: Structural Biology Is Coming Of Age
Neeraja Sankaran | Aug 21, 1994 | 6 min read
Coming Of Age Structural biology--the study of the three-dimensional shapes of biological macromolecules--has always been a facet of biological research, from the detection of cells in the earliest days of microscopy in the late 17th century to the first X-ray crystallographic images of proteins in the 1950s and the development of DNA technologies that made proteins more accessible for study through the 1970s and 1980s. BUILDING
Building On Firm Foundations: Structural Biology Is Coming Of Age
Neeraja Sankaran | Aug 21, 1994 | 6 min read
Coming Of Age Structural biology--the study of the three-dimensional shapes of biological macromolecules--has always been a facet of biological research, from the detection of cells in the earliest days of microscopy in the late 17th century to the first X-ray crystallographic images of proteins in the 1950s and the development of DNA technologies that made proteins more accessible for study through the 1970s and 1980s. BUILDING
Genome Guru
Karen Hopkin | Oct 1, 2009 | 7 min read
By Karen Hopkin Genome Guru With some creative coding, Tim Hubbard has helped scientists see into the future of biomedicine. © Cate Gillon Tim Hubbard claims he knows nothing about genetics. But he was drawn into the high-stakes world of genomics by a job offer he couldn’t refuse. Hubbard had been working on algorithms for predicting protein structures at the MRC Centre for Protein Engineering in the Un
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Notable
Jeffrey Perkel | Apr 14, 2002 | 4 min read
K. Rein et al., "The Drosophila standard brain," Current Biology, 12[3]:227-31, Feb. 5, 2002. "The authors present an approach to create a 3D image of the fly brain. This is a very useful resource tool that will make it possible to create an atlas of gene expression patterns and will be very useful for analyzing brain structure in mutant backgrounds." —Oliver Hobert, Columbia University College of Physicians and Surgeons, US X-Ray Crystallography F.J. Lopez-Jaramillo et al., "Crystalliz
Benefiting from the Human Genome
Jennifer Fisher Wilson | Apr 29, 2001 | 5 min read
As one of the leading causes of death in the United States, cancer continues to challenge those working in the field. Despite long-ongoing research, much work remains before cancer is eradicated. Really a large family of diseases, cancer requires diverse methods for treatment and diagnosis that will only come with a better knowledge of the basic biology of the affected systems. Advances in understanding the causes, new techniques for drug discovery, and increased funding of cancer research have
Genome Database Booms As Journals Take The Hard Line
Christopher Anderson | Oct 29, 1989 | 5 min read
For researchers in such fast-growing fields as gene sequencing and crystallography, the end of traditional scientific publications may be in sight. Quietly, over the last year, a trial program in the electronic submission of data has laid the foundations for a revolution that may someday replace the research journal as the vehicle for scientific communication. In an agreement With GenBank, the main U.S. gene sequence database, nearly a dozen journals are refusing to accept papers with sequ

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